Sho Goh Lab
@ShoGohLab
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We find out where RNA modifications are, what they do, how they do it and why that matters. Always looking to hire new postdocs
Joined May 2019
Achievement Unlocked! @huihuian521, our 1st PhD student’s 1st 1st-author paper! Out now in @MolecularCell 🧵 We identify the 1st m6Am Reader and uncover a novel and unexpected mechanistic role for this abundant yet enigmatic mRNA modification. (1) https://t.co/bVVVKNlXV7
cell.com
An et al. discover transcriptional terminator PCF11 as a m6Am reader and demonstrate that m6Am does not regulate mRNA stabilization but sequesters PCF11 to suppress premature termination and promote...
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Just finished giving the last talk at this amazing Asian RNA Club Symposium that was full of other talks and posters with new unpublished stories. Looking forward to the next Symposium in 2 years at Nara, Japan!
アジアRNA業界の至宝Narry Kimさんのご尽力で開催がようやく実現したAsia RNA Clubの記念すべき第一回ミーティングがソウル大学でいよいよ始まります！
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アジアRNA業界の至宝Narry Kimさんのご尽力で開催がようやく実現したAsia RNA Clubの記念すべき第一回ミーティングがソウル大学でいよいよ始まります！
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I was amazed by this tour de force to profile 16 different RNA modifications simultaneously when i first heard @SchragaSchwartz talk about it. I'm still amazed now. https://t.co/tQ1bWCHLZy
cell.com
Pan-Mod-seq enables systematic, multi-modification mapping of rRNA across life. Applying it to diverse organisms reveals that hyperthermophiles dynamically install stabilizing modifications to...
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Always great to have old friends visit us in SZ. Today, fellow HannonLab alumnus @Elvin_Wag from @IcahnMountSinai visited us at @ShenzhenBayLab to share his experience researching cancer stem cells, give career advice to our young scientists and enjoy our famous roast pigeon
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Why is it suddenly so difficult to buy phase-lock tubes? Anyone knows anyone who's still selling?
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Always been interested in the possible roles of RNA mods outside of the full-length RNA they are derived from. Following their earlier work of m6A nucleosides as receptor ligands, Ogawa et al identify how modified nucleosides can also cause toxicity https://t.co/OFMa4HryRm
cell.com
Ogawa et al. report that the intrinsically toxic RNA catabolites m6A, m6,6A, and i6A are detoxified through sequential action of ADK and ADAL, forming IMP. Disruption of this modified adenosine...
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LOL
For many of those who were asking on BLOW5 vs POD5 for nanopore signal data, here is a finally detailed benchmark we did: https://t.co/ZspXSlrW9e Summary: performance of BLOW5 is >= POD5 (from ~= to 100X, see below), with benefit of having ~3 dependencies instead of >50.
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For many of those who were asking on BLOW5 vs POD5 for nanopore signal data, here is a finally detailed benchmark we did: https://t.co/ZspXSlrW9e Summary: performance of BLOW5 is >= POD5 (from ~= to 100X, see below), with benefit of having ~3 dependencies instead of >50.
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I'm calling it: best graphical abstract for 2025.
Now online! Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes
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Congrats to Shino and @SamieJaffrey for this novel finding about how ribosomes play a role in the mechanism of m6A-driven mRNA degradation
Now online! m6A alters ribosome dynamics to initiate mRNA degradation
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So EJCs don't demarcate m6A topology?
The timeline of co-transcriptional #mRNA processing and #modification may have to be revised: cleavage, termination, and #m6A deposition may occur earlier than most #splicing! Potential textbook changing study by @EduEyras & Hayashi labs! @_AJSethi
https://t.co/mPCAo1Ly2M
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https://t.co/UGUFn362PP Excited to share this latest study from the lab. Kudos to Shumei and the team on establishing a precision oncology paradigm (CAN-Scan) with real-world impact and significance for colorectal cancer patients in the clinic.
cell.com
Chia et al. establish a platform called CAN-Scan that combines machine learning (ML) with advanced molecular genetic testing on patient-derived cancer cells. CAN-Scan uncovers key genetic features...
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New work from Xueyi and team: Chem-CLIP-Map, a method to map small molecule binding sites on RNA using nanopore sequencing and fragment analyzer. https://t.co/07XCr0UHkx
#RNA #ChemCLIP #DrugDiscovery
academic.oup.com
Abstract. Target validation and identification of binding sites are keys to the development of bioactive small molecules that target RNA. Herein, we descri
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Glad to have contributed to this study
We are happy to share that our SG-NEx manuscript (led by @chenying927, @nadia_davidson, @yukkeiwan and @JonathanGoeke), is now out with open access: https://t.co/om90nZHvlb, together with an update release of SG-NEx data v0.6.0!
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Thanks @shifengxue for inviting me to share our recent m6Am reader/monkey god story at NUS. I had a lot of fun learning about the importance of RNA in editing technologies and in butterfly evolution
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PCF11 strikes again! Yu Yang lab shows how PCF11 mediates transcriptional termination by promoting condensation. https://t.co/pEA2piE1iI
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Very happy to release the single cell and spatial long read RNA seq module for our transcript discovery and quantification tool Bambu (Bambu-clump)! The key challenges were dimensionality and accurate estimation of transcript expression with minimal data https://t.co/m9agMLFGCz
biorxiv.org
Single cell and spatial transcriptomics have dramatically changed how we can profile RNA from heterogenous biological samples. Combining single cell and spatial profiling with long read RNA-Seq...
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Gregor Mendel is so much cooler, and his life so much richer, than your high school biology class might suggest. Here are 12 things I recently learned about Mendel. 1. After his death, thousands of his pages (filled with data) were destroyed. Nobody knows why this happened.
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