Our new study shows that natalizumab treatment gap not only changes serum biomarkers (e.g. sVCAM-1), but also (subsequently) CSF composition, suggesting that renewed immune infiltration into the CNS and other tissues might play a role in reducing PML risk.

Our paper is out: the first genetic treatment response biomarker in MS. A finding only made possible by AIRRseq. This was a truly collaborative effort with @jsabatino37 @hwiendl @AdaptiveBiotech and is a huge step towards personalized medicine.

Our new AIRR paper alongside Ocrelizumab, thanks to @NFDI4Immuno and the whole team!

The next chapter in our continued effort to understand EBV and MS: Broader anti-EBV TCR repertoire in multiple sclerosis: disease specificity and treatment modulation

Structure-based prediction of T cell receptor recognition of unseen epitopes using TCRen. Yes, it works: https://t.co/A2XJe9Erbt

Rare diseases need some attention, too. Chemokine-mediated cell migration into the central nervous system in progressive multifocal leukoencephalopathy: Cell Reports Medicine

Glad to finally be able to showcase our #TCR-#epitope annotation tool DETECT and the cool results we have gotten with it at the @airr_community #AIRRC7 conference! And as of now you can use it yourself!

AIRR Community Meeting VII – Learnings and Perspectives: https://t.co/RnbtKJm28C

Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA New scientific commentary by Nicholas Schwab

I wrote a commentary about a new MS CSF scRNAseq study that was recently published in @Brain1878 Transcriptomics reveals CSF cellular composition in multiple sclerosis but detects no viral RNA

Our #OpenAccess paper on human CNS #macrophages went online today. It was a multi-year collaborative effort between clinician scientists from #Neuropathology #Neurosurgery #Oncology and #gynacology. It struck with the question: what are the phenotypes of human CNS macrophages? /1

The new special issue of #ScienceTranslationalMedicine is out! This issue features a collection of studies and articles exploring frontiers in #neuroimmunology and the role of the immune system in neurological conditions such as Parkinson's disease. https://t.co/FyevVOndrS

I wrote a review in @ScienceTM with my long-time collaborator @hwiendl about what we can learn about CNS immunity when we look closely at patients treated with interventions that target BBB trafficking.

Beautiful example of bedside -> bench -> bedside #Tcell immunology for the treatment of #autoimmunity https://t.co/fLSn3GuQeu

At this year’s ECTRIMS in Milano with the team #MSMilan2023

Also included is an exciting session devoted to identify the obstacles in turning AIRR-seq into a diagnostic tool

A new episode of #OnAIRR - the podcast of the AIRR Community is available. We discuss AIRR-seq, machine learning and disease diagnostics with @zazius, @ScottBoydLab. Subscribe and listen in your favourite app or grab the episode here:

A new episode of #OnAIRR - the podcast of the AIRR Community is available. Prof Xenophon Papademetris, @YaleRadiology, USA, introduces Software as a Medical Device. Subscribe and listen in your favourite app or grab the episode here:

Targeting MCAM for next-generation modulation of leucocyte trafficking

Today the funding starts for #Base4NFDI, @NFDI4Agri, @nfdi4bioimage, @nfdi4energy, @NFDI4Immuno, @NFDI4memory, @nfdi4objects and @nfdixcs. We warmly welcome you to our #NFDI network! #FDM #RDM #FAIRdata