Rob Beagrie
@RobBeagrie
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@WellcomeTrust Sir Henry Dale Fellow based at @HumanGeneticsOx, interested in chromatin disruption in human disease. He/him. Mastodon: [email protected]
UK
Joined June 2013
🚨 Job alert Hiring a postdoc (comp or wet lab) to work on chromatin & genetics 🧬 Come work with us @HumanGeneticsOx in the beautiful @UniofOxford 🗓️ Closing September 13th Details at https://t.co/TRLXH3hKfS Pls share and RT! #PostdocJobs #GeneticsJobs #genomics #cohesin
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Very happy to have been able to help out with this one - some very cool work! #genomics
Great collaboration between the @FoldingGenome and Watkins labs, reporting the first Gain of Function de novo enhancer causing Mendelian disease (ST Depression Syndrome), defining a multidisciplinary path with ML to solving non-coding clinical genetics. https://t.co/0ShPzik8Le
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Calling all rare disease researchers and clinicians who have a variant of uncertain significance... 🧬 The @MRCMouseNetwork & @NMGN_CongAnom (co-led by our PI @srftwigg) are currently looking for VUSs to model in mice! 🐭 (1/2)
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And it’s #PhDone! Rachel Kimber, first PhD student in my lab @BabrahamInst, has brilliantly defended her thesis today. Thanks to @carovinuesa and @viropractor for examining Rachael’s thesis. Well done, Dr. Kimber 🥳 🎉🥂
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Fantastic day talking science @BigDataIns. Thanks for the invitation to share our research @RobBeagrie - it was great to see some familiar faces (the lovely Yang Shi!), put some faces to names/emails, and meet some new!
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If you are willing to learn low input techniques to explore the chromatin of your favourite organism, don't hesitate to apply to this hands-on course! We'll be teaching you Low-C, ATAC-seq, CUT&RUN, and its bioinformatic pipelines.
🔊 Applications are open for our Low Input #Epigenomics course! #LowInput24 Learn how to apply the latest experimental and #computational approaches for studying #ChromatinBiology at both the gene and #genome-wide levels 📩Apply by 14 February 2024 🌐 https://t.co/2LsWhHhzhX
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Applications are now OPEN for an internship in my group at Oxford University. Open to UK undergraduates from under-represented and disadvantaged backgrounds – apply by Wednesday 21 February 2024 to join us this summer:
ox.ac.uk
What is UNIQ+?UNIQ+ Research Internships are designed to provide students from under-represented and disadvantaged backgrounds who are ordinarily resident in the UK with the opportunity to experience
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Very excited to share that our work reconstructing chromothripsis has now been published in @CellGenomics! We reconstructed chromosomes with up to 800 rearrangements on a single allele and queried epigenetic and transcriptomic consequences. Thread below! https://t.co/LWzYFYPPPV
cell.com
Ijaz et al. reconstructed chromothriptic and wild-type chromosomes in patient-derived esophageal adenocarcinoma organoids using a haplotype-aware method. Upon these assemblies, they layered epigene...
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Submissions for technology track presentations are also open - go to https://t.co/buYA714cZm and apply by May 10th to showcase your bioinformatics/molecular biology software or hardware to the community #Bioinformatics #ComputationalBiology #ISMB2024
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You can now submit your new, unpublished work for publication as a proceedings paper at ISMB 2024! Full details are available at https://t.co/4juJsUg224 - the deadline is January 25th #Bioinformatics #ComputationalBiology #ISMB2024
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Applications are now open for a fully funded @SoCoBioDtp PhD project with myself (@sotonbiosci ) and Jerome Swinny (@portsmouthuni) … please get in touch to discuss the project! Deadline Jan 8th.
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Is anyone here using the UKBiobank 200k genomes dataset? We are having some weird issues and are trying to troubleshoot if data vs code 😬 Anyone else seeing anything odd? Either way, please share! 🧬
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How cis-regulatory elements interact to regulate gene expression-role of CTCF and cohesin- check out our pre-prints @MRC_WIMM @jrmmhughes @FoldingGenome @RobBeagrie @JefBoeke @MolecularCell @NAR_Open @CTCF_Papers @generegulation
https://t.co/iQaza5Zc8G
https://t.co/f9RHDRYwpN
biorxiv.org
Enhancers and their target promoters often come into close physical proximity when activated. This proximity may be explained by a variety of mechanisms; most recently via cohesin-mediated chromatin...
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If you know what you want to do and are ready to jump straight into a project, you might be interested in a DPhil in Clinical Medicine https://t.co/nEDIpEMWON - happy to talk through the differences with any interested candidates 3/3
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There are two different DPhil programs you can apply to: if you want first-year rotations and more of a focus on computational biology then you might be interested in our DPhil in Genomic Medicine and Statistics https://t.co/snZeHOUPog 2/3
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Looking to do a PhD in 2024? Interested in gene regulation, chromatin and disease? Applications are now open so come join https://t.co/yYXhZr9dg1 at the @HumanGeneticsOx ! Further details below but if you're interested DM me to talk about possible projects. Deadline Dec 1st 1/3
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Multiplex-genome architecture mapping (multiplex-GAM) facilitates rapid, unbiased and ligation-free determination of chromatin interactions, as compared to Hi-C. @apombo1 @RobBeagrie @anto_scial @LonnieRWelch @LabPombo @helmholtz_de
https://t.co/eyfVaNuzZA
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Multiplex GAM is out! Congrats @LabPombo @apombo1 !! Coming to a brain near you!! https://t.co/1730QP365M
nature.com
Nature Methods - Multiplex-genome architecture mapping (multiplex-GAM) enables rapid, unbiased, ligation-free mapping of genome-wide chromatin interactions.
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Multiplex-genome architecture mapping (multiplex-GAM) facilitates rapid, unbiased and ligation-free determination of chromatin interactions, as compared to Hi-C. @apombo1 @RobBeagrie @anto_scial @LonnieRWelch @LabPombo @helmholtz_de
https://t.co/eyfVaNuzZA
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The paper about CIARA - our method to find rare cells in scRNAseq data - is now published in Development! One of the major additions to the preprint is the analysis of scATAC-seq datasets, showing how CIARA can find rare cells in other types of single-cell omic datasets too.
CIARA: a cluster-independent algorithm for identifying markers of rare cell types from single-cell sequencing data Read this Techniques and Resources Article by Gabriele Lubatti, Marco Stock, Ane Iturbide, @anto_scial & colleagues @HelmholtzMunich: https://t.co/846oH7dLXf
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