🧬 Monoclonal Antibody Nomenclature (WHO 2021 Update) 💡 The WHO completely revised antibody naming rules in 2021. The old –omab / –ximab / –zumab / –umab endings (based on murine → human origin) are obsolete. Now, antibodies are classified by structure, function, and

😷 When Lupus Isn’t Lupus - Meet Lupus Pernio! 🧴 What it is: A chronic, indurated, violaceous lesion of the face - especially the nose, cheeks, lips, and ears. ✨ A hallmark of chronic cutaneous sarcoidosis, not systemic lupus erythematosus. 🔬 Cause & Pathology: 🧫

🧬 Going Beneath the Skin - Lupus Profundus Demystified 🦋 Definition: Chronic autoimmune inflammation of the deep dermis and subcutaneous fat, seen alone or with DLE/SLE. 🧬 Pathophysiology: 🔹 Immune complex & complement activation 🔹 Leads to fat necrosis → fibrosis →

💖 Breaking the Chain: Blocking FcRn to Protect the Fetal Heart 🎯 Objective Assess the feasibility and safety of FcRn blockade (rozanolixizumab) to prevent recurrent cardiac neonatal lupus (cardiac-NL) in a high-risk pregnancy. 🧩 Background •💔 Cardiac-NL is due to

🩻 On This Day in History - November 8, 1895 ✨ Discovery of X-rays! ⚡ While experimenting with cathode rays, German physicist Wilhelm Conrad Röntgen noticed a strange fluorescent glow on a nearby screen - even though the tube was covered. 👀 He had discovered invisible rays

🧬 Atacicept in IgA Nephropathy (ORIGIN 3 Trial) Background: •IgA nephropathy (IgAN) → Most common primary glomerulopathy globally. •B-cell–driven disease → Mesangial IgA immune complex deposition. •~50% progress to kidney failure or death in 10–20 years. •Atacicept =

⚡ “Even my enemy shouldn’t get this disease.” – Salman Khan 💬 🧠 “The Suicide Disease” He was talking about Trigeminal Neuralgia, a rare condition causing sudden, electric shock–like facial pain ⚡ Often called the “suicide disease.” Unbearable, yet treatable with meds or

1/2 #Takayasu arteritis #TAK is a rare large vessel vasculitis #LVV. TAK more commonly affects young females.Our review in @NatRevRheumatol covers the latest in the pathophysiology, diagnosis and treatment of #Takayasu arteritis. https://t.co/ZqAYptAjzT   Pathophysiology:

🦋💫 Lupus Can Do This Too! 💜 Lupus Peritonitis 🦋 Definition: Inflammation of the peritoneum as part of systemic lupus erythematosus (SLE) - a form of lupus serositis. Rare but important! 🔬 Pathophysiology 🧬 Immune complex deposition in the peritoneum 🔥 Complement

📘 Takayasu Arteritis - Nature Reviews Rheumatology 2025 The review provides a comprehensive update for clinicians and researchers on pathophysiology, diagnosis, and management of TAK. #RheumattDoc #MedTwitter #RheumTwitter #rheumatology #Naturereviewsrheumatology @DrAkhilX

🧬 🆕 New Drug : Oral Icotrokinra for Plaque Psoriasis (ICONIC-LEAD, NEJM 2025) 💡 Background: 🔸 Icotrokinra is a targeted oral peptide that selectively binds the interleukin-23 (IL-23) receptor, blocking IL-23 signaling - a key driver of psoriatic inflammation. 🔸 Designed to

🔄 Leflunomide Washout Therapy 💊 Why Washout Is Needed 🧬 Leflunomide → Teriflunomide (active metabolite) 🕒 Very long half-life (~2 weeks) → may persist up to 2 years 📍 Indications: 🚼 Pregnancy planned ⚠️ Severe toxicity (hepatotoxicity, pancytopenia, infection) 🔄

Everyone seems to have typhoid these days - thanks to the Widal test! @IhabFathiSulima @DrAkhilX @CelestinoGutirr @DrNikhilMD #MedTwitter

🩸 Pyoderma Gangrenosum: The Great Mimicker 🧬 What it is 🔥 A neutrophilic dermatosis causing painful, rapidly expanding ulcers with violaceous, undermined edges. 🚫 Not an infection! ⚡ Often triggered by minor trauma (pathergy phenomenon). ⚙️ Pathogenesis 🧠 Immune

🎭 Rashomon Effect in Medicine 🩺 Meaning: When different people - doctors, patients, or observers - interpret the same medical event in different ways, influenced by their background, training, or emotions. 🎥 Origin: Named after Akira Kurosawa’s 1950 film “Rashomon”, where

2025 ACR Recommendations for Extrarenal SLE Management! 💊 HCQ (Hydroxychloroquine) – for all patients (unless contraindicated) 🧴 Glucocorticoids – use only if necessary → 💉 lowest dose, shortest duration 📉 Taper to ≤5 mg/day by 6 months (ideally to zero) ⚡ Pulse

Every milestone is built on perseverance, learning, and guidance. Grateful to have graduated with DM in Clinical Immunology & Rheumatology from Christian Medical College, Vellore. Heartfelt thanks to my mentors, Dr. John Mathew (Professor & Head of Department), Dr. Ruchika Goel,

True that!

When you spend too much time on social media.