Robert Fledrich
@RFledrich
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Professor of Neuroanatomy @UniLeipzig. Interested in myelin disorders and regeneration. Find me there: @[email protected]
Leipzig
Joined June 2018
Excited to share the latest study on peripheral nerve repair by the Stassart/Fledrich lab! See how Schwann cells communicate with adipocytes to adjust their metabolism for successful regeneration.
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Dear fellow scientists, please come to Bluesky. It’s a beautiful place
medpagetoday.com
Many compare it to the early days of Twitter
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Thrilled that the DFG will fund our #NeuroTune graduate school in Leipzig with €5.7M for 5 tandem projects creating over 40 PhD positions. The Stassart/Fledrich lab is proud to host two projects, exploring adaptive myelination in diverse contexts. https://t.co/dgT91Lpors
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A myelinic channel system for organelle transport to the glial-axonal junction https://t.co/NX4LTWoZHo Thanks to all co-authors on and off X @KlausNave @werner_hauke @DrChapple @tabifromengland @Lina_Komarek @ColinPhD @RebeccaSmithPhD @MacpEuan
biorxiv.org
Myelin sheaths comprise compacted layers of oligodendroglial membrane wrapped spirally around axons. Each sheath, if imagined unwrapped, has a cytoplasm-filled space at its perimeter, linking it to...
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A beautiful study showing how PMP22 affects the lipid metabolism of Schwann cells in CMT1A.
I'm very proud that my main study from my PhD is finally out in the journal Brain! This was a huge collaborative project that took several years but I'm happy with the result!
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Happy to share that my PhD project found a home with @EmboMolMed! We pharmacologically and genetically modified aberrant myelin growth in rodent models of PMP22 gene dosage diseases. Details below 🧵
Targeting PI3K/Akt/mTOR signaling in rodent models of #PMP22 gene-dosage diseases. By D. Krauter, M.W. Sereda & colleagues @mpi_nat
#PeripheralNeuropathies 🗞️ https://t.co/hgBy1G4qcL
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We are looking for a postdoc to investigate behavioural & functional correlates in zebrafish with mutations in autism genes. Great opportunity to develop a new research direction towards studying the role of glia in neurodevelopmental disorders. Please RT
elxw.fa.em3.oraclecloud.com
We are looking for a postdoctoral researcher to identify converging and diverging correlates of neural circuit dysfunction in zebrafish with mutations in risk genes for autism spectrum disorders....
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Happy to be part of this nice review in Cold Spring Harbor Perspectives in Biology with @ruth_stassart and Alison Lloyd https://t.co/UBsigPPVEy
@isabial_iis @NeuroAlc
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With the passing of Laura Feltri we lost a valued colleague who made incredible contributions to PNS research and beyond. She leaves behind a legacy that will be remembered. My deepest condolences to her family and friends.
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🚨We are hiring at the postdoctoral level. 🚨 RT very much appreciated!🤗
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Injury to peripheral #nerves in the body can result in pain and movement disorders. Scientists at #UniLeipzig have recently investigated how damaged nerves can regenerate better. Fatty tissue supports the healing process. #Medicine @RFledrich
https://t.co/NKMaGUiHWh
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New! Online now: Adipo-glial signaling mediates metabolic adaptation in peripheral nerve regeneration https://t.co/EXYNuOt9dJ
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Great job @vks24865, Vlad and Nele! Big thanks to @DoctorPAF , @pepegosaelx , @ClaraMutschler, @annaslbch, @emh_es, @TheresaKungl, @KlausNave, @ost_mario and everybody involved!
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Acute nerve injury triggers leptin receptor expression by Schwann cells. Leptin released from adipose tissue then stimulates mitochondrial respiration and myelin autophagy in Schwann cells to promote nerve repair.
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So yes, our paper is out! https://t.co/7ZlrZU5L4k Here's how the story unfolded - thread below🧵👇
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New study on multiple sclerosis: Myelin may be detrimental to nerve fibres. Joint research by #UniLeipzig and @mpi_nat. @RFledrich
https://t.co/AUNp3S2HnY
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Myelin turns into a risk factor for axons in #MultipleSclerosis. Team work by Stassart/Fledrich and @KlausNave labs. High five to 1st authors @marboschqueralt and Erik Schäffner, thx to @JuliaEdgar1 , @HAL4K, @TingSun_MPINAT and everyone who contributed!
nature.com
Nature Neuroscience - Myelin is widely believed to protect axons from damage in multiple sclerosis. The authors challenge this view and find that myelin insulation renders axons more vulnerable to...
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Do you agree that animal research is essential in #Biology & #MedicalResearch? 📢The EU will be discussing a complete ban of animal research - Please support this initiative pro animal research in Europe & spread the word 🙏 https://t.co/HQab9RQrUQ
braincouncil.eu
Support Pledge for Science calling for the prioritisation of brain research & innovation in the EU
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Delighted to see our work highlighted on the cover of JCB. What a great celebration of a brilliant PhD thesis by our talented Nina Kozar-Gillan. @ninakozar et al @JCellBiol ( https://t.co/zKHm2Nfb2X)
@EdinUniNeuro
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Happy to share great work from @DoctorPAF lab, thanks to the wonderful work of @shaline_v, @ClaraMutschler and our lab @MyelinAlicante. Thanks also to @MonkLab1, Robin, Roger, Benjamin and especially @Lab_Coleman for their support.
frontiersin.org
Since SARM1 mutations have been identified in human neurological disease, SARM1 inhibition has become an attractive therapeutic strategy to preserve axons in...
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