Ploegh lab
@PloeghLab
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Student/postdoc run twitter for lab of Hidde Ploegh
Joined November 2019
Thank you to our wonderful collaborators for their support @danmucida @victora_lab @SetteLab @timlu @ejalm Twitterless Jim Moon and all the co-authors!
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A conserved Bacteroidetes antigen induces anti-inflammatory intestinal T lymphocytes https://t.co/2RNmo8Gq6r Awesome collaboration with far reaching implications. CD4 T cells of a single specificity can recognize a variety of abundant commensals and elicit regulatory responses.
pubmed.ncbi.nlm.nih.gov
The microbiome contributes to the development and maturation of the immune system. In response to commensal bacteria, intestinal CD4+ T lymphocytes differentiate into functional subtypes with...
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👇👇👇💪💪💪
Very happy to share our new study @ScienceMagazine, showing that members of the Bacteroidetes phylum can induce anti-inflammatory intestinal lymphocytes. Huge shoutout to @DjenetBousbaine who led this work. Brava! 1/
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I am thrilled to share my PhD work @MicrobiologyMit @MITBiology @BostonChildrens out today at @ScienceMagazine. 1/ https://t.co/YnCtYSGEgB
science.org
In a mouse model of colitis, a commensal-derived antigen drives regulatory immune responses in the intestine.
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In @ScienceMagazine this week, @DjenetBousbaine, @PloeghLab, @ambilate, & al report peptides derived from β-hexosaminidase—a highly conserved enzyme produced by #Bacteroidetes commensals—drives regulatory CD4+CD8αα+ #IEL differentiation in #gut! https://t.co/AFLNh0o5JY
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@ScienceMagazine @DjenetBousbaine @PloeghLab @ambilate Please also be sure to check out the accompanying Perspective by Meera Shenoy & @KochMeghan! https://t.co/Ul6ymzRs4L
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Cool discovery in @ScienceMagazine that could have implications for #inflammatoryboweldisease. @DjenetBousbaine in @PloeghLab find that an antigen shared by many members of the gut microbiome elicits certain regulatory T cells that suppress inflammation. https://t.co/w1zF9NgNSC.
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Check out the last paper from the @ploeghlab! Beautiful teamwork between our former PhD student @DjenetBousbaine and former postdoc @ambilate. https://t.co/BxKg9ewe8l
science.org
In a mouse model of colitis, a commensal-derived antigen drives regulatory immune responses in the intestine.
In @ScienceMagazine this week, @DjenetBousbaine, @PloeghLab, @ambilate, & al report peptides derived from β-hexosaminidase—a highly conserved enzyme produced by #Bacteroidetes commensals—drives regulatory CD4+CD8αα+ #IEL differentiation in #gut! https://t.co/AFLNh0o5JY
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Nanobodies are amazing tools to noninvasively image specific subsets of immune cells (allowing, for example, monitoring the progress of immunotherapy). Together with @PloeghLab, we wrote a review article @OncologyAdvance on this subject @DanaFarberNews
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Thrilled to share our work on the recognition of commensal-derived antigen by CD4 CD8aa T cells in a transnuclear mouse model developed in our lab. These T cells help to temper harmful immune responses in the gut Stellar work by @DjenetBousbaine @biorxiv
biorxiv.org
The microbiome contributes to the development and maturation of the immune system[1][1]–[3][2] In response to commensal bacteria, CD4+ T cells can differentiate into distinct functional subtypes with...
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The Ploegh Lab is looking to hire a postdoctoral researcher with experience in chemistry--see our posting: https://t.co/uuPZj3EP9J And our new lab website: https://t.co/flLjtY0LCt
@Chemjobber
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