Peter Yeow
@PeterYeowZY
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Postdoc @Ahollandlab @JohnsHopkinsMBG DPhil @Chapman_lab_uk @UniofOxford Funded by @astar_research, Singapore.
Oxford, United Kingdom
Joined September 2020
Happy to see this out in @naturesmb, a wonderful 🎂 present! Big thanks to all co-authors, @DimitrisTypas for the editorial handling, and @BastoRenata for the News & Views article.
Interested in E3-Ub ligase regulation? Check out the latest paper from our lab: Big congrats to @PeterYeowZY who conceived and drove this study!.
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Full preprint here: we welcome feedback and questions, thanks! 🙏.
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3️⃣Impact: This explains why PLK4 inhibitors are so potent in TRIM37-high cancers. Surrogate MTOCs don’t stand a chance here—TRIM37 degrades them upon formation (optogenetic assays⬇��, compare WT vs E3 dead). Model also explains TRIM37 patient mutations in Mulibrey Nanism. -🔗below
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2️⃣ Model: My work at @ahollandlab suggests a shared blueprint within the TRIM family for assembly regulation. Akin to TRIM5a in HIV restriction, TRIM37 employs an assembly-driven E3 activation process but is uniquely tailored for MTOC control via its TRAF domain. ➡️Impact
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📝Preprint! 1️⃣Question: How are large MTOC structures regulated by an E3 ligase? 🧵In 2020, we showed TRIM37 suppresses surrogate MTOC structures in 17q23 cancers, see ⬇️). But TRIM37 also regulates centrosomes and pathological MTOCs (Gönczy/Oegema/Desai labs). How?? ➡️our model
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Congrats on this wonderful work buddy @2primehydroxyl ! Glad to see this out, a real eye-opener to what ribosomes can do 🫣 but centrosomes might still be cooler 🍻.
We’re excited to share our study in @CellCellPress on the role of the MAP3 kinase ZAK in UV-induced apoptosis led by @2primehydroxyl! We studied cell signaling kinetics following UV-damage and found that ZAK drives apoptosis via ribosome collisions.
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RT @UniofOxford: A study has uncovered a genetic vulnerability present in nearly 10% percent of all breast cancers tumours, and found a way….
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RT @Chapman_lab_UK: Just out @Nature. Work from us & @AHollandLab shows recurrent 17q23-amplification in breast cancer renders cells comple….
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