We are excited to share our two back-to-back papers in @JOC_OL! 🚀 We studied how conformations affect the cycloisomerization of 1-bromoalkynes, highlighting the key role of a methyl group on the cyclohexane ring.

🚨 Check out the latest chapter of Comprehensive Organic Synthesis (3rd ed.) — a deep dive into allyl borons! 🤠 #OrganicChemistry #Synthesis. https://t.co/wDA9mcReab

Honored to see two of our recent @JOC_OL publications among the most read this month!! Check them out in the following post(I also leave the link of our third OL this month, which will appear back-to-back with the second one). Thanks to the readers of @JOC_OL for the interest

Special thanks to @MorenRmm and @OmarartoOAS for the outstanding synthetic work, to Prof. Haberhauer and his team for the calculations, to Isabel for her detailed NMR studies, and to @PabloBarrioChem for his guidance throughout the project. 🙌

At PbLab we are moving toward more complex systems, studying new variables to unlock regioselective reactivity. Collaborations with leading groups will broaden the impact of our work. Stay tuned! 👀

Extending this study to terpene-derived trisubstituted systems, we discovered a new reaction pathway: a 5-exo-dig process on unactivated C–H bonds, not previously observed in this context. https://t.co/NSDCFGKeRj

🎉Our new scientific contribution is out now!!🎉Herein we present an overview of how the conformational effects affect the outcome of our gold(I)-catalyzed cycloisomerizarion of 1-Bromoalkynes. (1/3) https://t.co/YHb0LkbxSX

Again, thanks to @PabloBarrioChem for the opportunity, to Dr. Merino for the meticulous NMR characterization, and the Haberhauer team for the calculations. Special thanks to @MorenRmm for his enormous contribution — check his profile for more details!!!✨(4/4)

✨I'm also very happy to announce that the second part of our study is out now in @JOC_OL!!✨ Herein we present an overview of how conformational effects influence the outcome of our gold(I)-catalyzed cycloisomerization of 1-Bromoalkynes. (1/4)

By using terpenes as nature-given stereochemical probes, we can access highly complex substituted substrates. Moreover, conformational effects not only rule selectivity but also reactivity. A preliminary study of the 5-exo-dig cyclization is presented. (2/4)

This 5-exo-dig transformation shows some really interesting features which are currently being studied at @PbLabUniOvi. We are so excited to share our work with the community. Please, stay tuned to find out more about these powerful transformations!!!✨(3/4)

Thanks to everyone who contributed to this project, especially @OmarartoOAS for the outstanding synthetic work (stay tuned for what’s next) and @PabloBarrioChem for guiding us along this path. Check out 🧐:

In terpene derivatives we discovered a new 5-exo-dig reactivity, unprecedented on electronically unactivated C–H bonds. The mechanism, under study by @OmarartoOAS, may involve an endo vinyl cation-type transition state, a species not previously observed.

By studying conformational effects in terpene derivatives, we discovered the functionalization of unactivated C–H bonds at the 6-position, accessing diverse architectures, e.g., a particularly striking spirocyclic structure. The scope and mechanism are still under investigation.

Over the past years we studied the cycloisomerization of 1-bromoalkynes under gold(I) catalysis, showing that unactivated C–H bonds at the 5-position can be functionalized without directing groups, via a vinyl cation-type transition state and 5-endo-dig reactivity.

🎉 Good news! Our latest work has just been published in @JOC_OL. In this study, we focused on the conformational effects in the cycloisomerization of 1-bromoalkynes under gold(I) catalysis. A perfect playground to see how small changes reshape outcomes.

My first work with anomeric amides has just been published in @Synthesis_1969! Thanks to all collaborators, especially Julia and Mark. We report new derivatives with faster kinetics and higher yields, providing insight into stereoelectronic effects in nitrogen-deletion reactions.

Check out the recent paper: “Approach to Heterospirocycles for Medicinal Chemistry”, co-authored by Carlos Rodríguez-Arias, Rubén Miguélez, Yuliia Holota, Pavel Mykhailiuk (@MykhailiukChem), and Pablo Barrio. This study describes the application of the gold(I)-catalyzed

Check out our last collaboration with @MykhailiukChem in @JOC_OL Approach to Heterospirocycles for Medicinal Chemistry. All the credit to @MorenRmm and Carlos Rodriguez

@MykhailiukChem @PabloBarrioChem @MorenRmm