Nucleus Genomics
@nucleusgenomics
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Your portal to complete self-knowledge.
New York
Joined December 2021
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Optimize everything — especially your health. Nucleus is now live at
We provide the most complete look into your genetic risks for diseases that’s ever been available.
Preorder the Nucleus whole-genome DNA kit today.
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We are incredibly excited to share that we’ve raised $14 million in new funding, led by
@AlexisOhanian
at
@sevensevensix
! We are reimagining personalized healthcare, starting with DTC genetic testing. Learn more 👇and join us:
Excited to announce that
@Nucleusgenomics
has raised $14m in seed+ funding led by
@alexisohanian
at
@sevensevensix
. Particip. from
@foundersfund
,
@ShrugCap
,
@hbarra
,
@alexandravbotez
,
@packyM
,
@Austen
, and many others.
Our vision is simple: a human genome on every smartphone.
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Nucleus Premium starts with whole-genome sequencing, the only DNA analysis that reads all your DNA.
We give you the most complete look into how your DNA shapes your health that’s ever been available.
Preorder your kit:
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We're Nucleus, the health platform for your DNA.
Our innovative analysis gives you the insights you need to live your healthiest life. It’s the most complete look into your DNA — ever.
Waitlist:
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Nucleus is proud to be working alongside
@illumina
to bring accessible, high-quality whole-genome sequencing to the public.
Our innovative DNA analyses with the newest sequencing technology give you the most comprehensive look into your health — ever.
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Your DNA helps shape your health. So does your lifestyle.
That’s why Nucleus combines your DNA with unique factors like your height, weight, and cholesterol, to distill your health risks into personalized results you can use to take action.
Waitlist:
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Premium DNA analysis in three steps.
Whole-genome sequencing from Nucleus is simple: Order, swab, send it back. Uncover how your DNA influences your health, starting with the disease risks you need to know.
Preorder your kit:
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How do ever-changing factors like your age, cholesterol levels, & BMI combine with your DNA to shape your chances for developing a disease?
We update your results as your risks change so you can uncover real-time information to protect your health.
One test, lifelong benefits.
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A DNA test that eclipses all the others. Whole-genome sequencing is the only DNA test that reads all your DNA.
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We find millions of genetic differences that other tests miss — including those that are most important to your health — so you can understand your health story, starting with your unique disease risks.
Waitlist:
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Introducing Nucleus Basic results. Thank you to the first-ever members who uploaded DNA data for a preview of our innovative analysis.
Got your reports already? Here's what you'll discover →
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Old genetic tests analyze less than 0.1% of your DNA. Nucleus whole-genome sequencing analyzes nearly all of it.
A new era of personal health — exclusively from Nucleus.
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Ever wondered why a disease runs in your family — but not everyone else’s? Your DNA might help explain.
Innovative scores from Nucleus compare your disease risks to people of the same ancestry.
Precise comparisons → meaningful insights → better choices
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Nucleus Premium whole-genome results coming soon 👀
Dramatically better health insights, thanks to an analysis of 1,000 times more DNA than tests like 23andMe and Ancestry.
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We are proud to learn from several studies co-authored by our CSO
@lassefolkersen
to inform the way we present our innovative polygenic scores to users.
Thank you
@GenomeWeb
for reporting on our work at the frontier of consumer genomics.
Thank you
@GenomeWeb
for noting how
@Nucleusgenomics
is bringing more accessible polygenic scores to the masses.
"Nucleus Genomics...is also learning from these studies [by] investing in communication, product design, and user interface and experience."
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You and your best friend share a lot — including 99.5% of your DNA. But what about the differences? Find out how those shape your health with Nucleus.
Uncover your unique health story. Waitlist →
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Nucleus Premium is the all-in-one genetic test, analyzing nearly all your DNA to identify your risks for common diseases — like asthma and migraines — and rare genetic conditions.
How?
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Nucleus is the all-in-one DNA test, capturing DNA differences that influence your risk for common and rare diseases for the most comprehensive look yet into your health.
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Prostate cancer is the second most common cancer among men in the US, predicted to cause over 30,000 deaths this year.
That number is rising: After two decades of decline, more men are now being diagnosed with advanced prostate cancer that’s less likely to respond to treatment→
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Complete insights into how your DNA shapes you, now and in the future.
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New reports. New insights.
We analyze your DNA to illuminate your unique health risks. Your Nucleus membership is a gateway to a constantly growing collection of insights — so you can capture your whole health story.
Waitlist:
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Did you know that more than 9,000 variants in the BRCA1 & BRCA2 genes are known to increase breast cancer risk, but old DNA tests look for only around 40 of these variants?
Nucleus Premium looks for thousands with whole-genome sequencing. Preorder today:
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Our innovative genetic analysis is also the most secure. Nucleus is the only whole-genome platform that sequences every sample in the U.S. on U.S. machines.
Quality and security combined with the all-in-one genetic test.
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Nucleus goes even further by personalizing your whole-genome analysis with unique lifestyle factors — like your age, sex, BMI, cholesterol levels, and more.
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Proud to sponsor
@dwarkesh_sp
’s chat with
@OpenAI
’s cofounder
@johnschulman2
.
Your DNA shapes everything about you. Want to know how?
Take 10% off our Premium DNA kit with code DWARKESH at
Here's my episode with
@johnschulman2
(cofounder of OpenAI & led ChatGPT creation)
On how post-training tames the shoggoth, and the nature of the progress to come...
Links below. Enjoy!
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Not enough people know the difference that detailed DNA insights can make at any age.
@alexisohanian
offers a great example here.
Let’s take a look:
@Nucleusgenomics
@KianSadeghi5
As the father of two girls (and son of a mom who had breast cancer, which she survived, but then died to brain cancer - which we were told wasn't connected) it's a drag to see I'm passing along these genes, but I'm grateful to know about it so we can better plan.
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Whole-genome sequencing is the only DNA test that can read all your DNA. Old DNA tests stop at less than 0.1% — meaning you miss insights that matter.
Preorder Nucleus Premium for the most complete possible look into how your DNA shapes you.
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This means our reports evolve with you. If your lifestyle factors change, or if scientists learn more about a disease, we’ll update your results.
We’re building a health platform, where DNA is the start of your health journey.
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We use advanced sequencing technology to capture the unique influence of millions of DNA letters on your health, along with rare DNA differences that can have big impacts on their own.
Your DNA becomes a window into your disease risks.
Preorder Premium:
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Just like you can’t understand a book from a single word, you can’t understand your health from a single gene.
Nucleus Premium is an all-in-one look at how DNA shapes your health, from the combined effect of millions of tiny DNA differences to rare variants with big impacts.
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Nucleus is your lifelong health companion. Welcome:
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Happy
#DNADay
! Today, we celebrate the first complete sequence of human DNA, a milestone in the quest to understand ourselves. Our mission is to fulfill that quest.
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Nucleus Premium gives you the most complete analysis of your disease risks, starting with your DNA. We answer two major questions about your health:
→ Which diseases am I at a higher risk for due to my DNA?
→ How will my risks change over time?
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DNA is the foundation of health. Knowing your genetic risks is the ultimate biohack.
The full body checkup / baseline list
$500
@function_health
bloodwork
$430
@nucleusgenomics
30x whole genome sequencing
$2500
@prenuvo
full body MRI
$180 athletic therapist assessment
A colonoscopy
A CAC scan
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Better price, quality, and security. With
@illumina
, we are proud to sequence your DNA in America and on American machines.
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Your DNA is the foundation of your health — but most DNA tests can’t capture the full picture.
Unlike those tests, Nucleus analyzes nearly all your DNA, meaning more insights into your health, from ADHD and insomnia to rare conditions.
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it's time for DNA insights to do the most good for the most people
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You know diabetes, smoking, high blood pressure, & high cholesterol increase your heart disease risk. But what about your DNA?
With these factors + a complete read of your DNA, we uncover your individual risk so you can stay proactive.
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Some DNA differences cause diseases on their own. But most diseases are influenced by factors beyond DNA.
This is why we combine the effect of millions of DNA differences with other elements — like your BMI & cholesterol — to capture your unique risks.
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Your DNA is a key part of what makes you unique. But Nucleus goes beyond your DNA.
We incorporate changing factors like your age, BMI, cholesterol, and more so your insights evolve with you.
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Cutting-edge DNA analysis that explores a greater breadth of diseases and traits.
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What if you could know every disease you’re at risk for — without setting foot in a doctor’s office?
…and no, it’s not a blood test. Here’s how your DNA can do that:
Scientists first sequenced an entire human DNA sequence in 2003. It was the first time we could trace the roots
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Nucleus Premium is your portal to complete self-discovery.
Our clinical-grade whole-genome sequencing kit provides an analysis 1,000 times deeper than old DNA tests. That means you get more accurate insights into disease you’re at risk for, and deeper insights into who you are.
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Waitlist at
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Nucleus Premium whole-genome DNA kits shipped...👀
Let us know when you get yours!
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We analyzed over 1 million DNA differences to uncover
@alexisohanian
’s breast cancer risk. His risk is slightly higher, possibly helping explain his family history.
Nucleus Premium, coming this summer, will look for rare variants with big impacts that can run in families.
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Nucleus is on a mission to revolutionize genetic testing.
Founder and CEO
@kiansadeghi5
on
@businessbarista
's Founder's Journal:
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There are millions of tiny DNA differences that work together to shape your risk for many diseases, especially cancers.
We scan your DNA to uncover their collective impact on you, comparing your risks to people who share your ancestry.
Say hi to your common genetic score!
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Be part of the next batch:
Proud to say
@nucleusgenomics
is ahead of schedule. First batch of preorders went out today — beating our summer deadline. We are here to serve you!!!!!!!!! 🫡🫡🫡🫡🚀🚀🚀🚀
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We are revitalizing consumer genetic analysis, giving you a more complete and accurate assessment of your genetic dispositions across a wider range of diseases and traits. We do this all while letting you maintain complete data ownership and control.
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Knowing your cancer risks helps you advocate for yourself — and take proactive steps like getting a screening or visiting a specialist.
Nucleus Premium uncovers rare DNA variants for colorectal cancer, breast cancer, prostate cancer, and gastric cancer.
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@michelecanzi
@KianSadeghi5
Can't wait for you to get your results! Let us know what you're curious about🤩
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For next-generation personalized insight — join our waitlist today:
Read our press release:
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Genetic insights can also help you mitigate health risks before they compound
For rare variants linked to colorectal cancer — the second most deadly cancer in the U.S. — regular screenings as early as age 20 can help catch tumors before they’re cancerous
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Want a preview of our analysis? Nucleus Basic can provide new insights into your health if you’ve done a DNA test before.
Upload your DNA for a taste of our analysis, or preorder Nucleus Premium:
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Our Premium analysis analyzes all of your DNA, looking for tens of thousands of rare variants old DNA tests miss –– ironically, the variants that can have the biggest impacts.
We're among the only DNA tests that provide a complete analysis of your common & rare genetic variants.
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We believe communicating where scientific knowledge stands today — without sensationalism or obfuscation — will pave the way for truth and scientific progress.
The Nucleus manifesto:
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So excited to ship the first batch of Nucleus Premium DNA kits today. It’s simple: Order your kit, swab your cheek, send your sample back.
We’ll give you the most complete possible look into your genetic risk for almost two dozen diseases.
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Nucleus whole-genome sequencing finds tens of thousands of rare DNA differences that old tests miss.
It's the most complete possible look into your genetic risks for diseases — including colorectal cancer, prostate cancer, breast cancer, and gastric cancer — that's ever been
Nearly 500-word article on preventing colon cancer & NO mention of genetics. There are 13,000+ DNA variants that substantially increase your risk for colon cancer.
If you have one of these variants, starting cancer screenings early can save your life.
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Consumer genetic testing is severely broken — but we are here to fix it.
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@MarkVillacampa
Yes! If you preorder the Nucleus Premium kit, you will be able to download your whole-genome data from our platform at any time.
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@jasonljin
"...the more you can change and guide your own destiny."
Exactly! Can't wait to deliver Premium results 🙌
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Freeing genetic insights that can help prevent these kinds of deaths is why we exist.
Scientists have learned a lot about the genetics of cancer — including that catching cancers early saves lives.
But that knowledge hasn’t yet benefited people.
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The most complete look into your DNA that's ever been available is almost here! 🧬
Order your kit today to join our next batch:
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Also, these variants aren’t always as rare as they seem. In fact, more than 2 million people in the U.S. have a DNA variant that can cause a preventable disease. Most of them don’t know it.
But what if they did know? Lives would be longer and healthier.
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The Nucleus Premium prostate cancer report analyzes 22,000 rare genetic variants that can dramatically increase the risk of the disease.
We also analyze over 1 million common DNA variants that can collectively increase prostate cancer risk.
Clinical-grade insights, no barriers.
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But DNA isn’t the whole story — especially for common diseases like heart disease and type 2 diabetes. That’s why we then combine your DNA with factors like your age, BMI, cholesterol & more.
That tells you your absolute risk, or your individual chance for developing a disease.
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Access the full range of scientific knowledge of how DNA shapes you and your health, now and in the future, with Nucleus Premium.
Still reading? Might be time to preorder:
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@madhavshroff99
@KianSadeghi5
@lassefolkersen
Hi there! 23andMe looks at less than 0.1% of your DNA. We look at nearly all of it.
@KianSadeghi5
did a great thread on this for more details:
Lots of people have asked about the difference between
@Nucleusgenomics
& companies like 23andMe, Ancestry, & MyHeritage.
TL;DR: Those tests look at less than 0.1% of your DNA. The Nucleus Premium whole-genome DNA kit looks at nearly all of it.
Here’s the long answer:
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→ How will my risks change over time?
We account for lifestyle factors that change your risks so you get accurate insights that evolve with you.
For example, your sex, cholesterol, blood pressure, & whether you smoke or have diabetes changes your risk for heart disease.
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@reclaiminit
@alexisohanian
@KianSadeghi5
For now, our Premium whole-genome DNA test is only available in the U.S.
Learn more here:
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@ErikaWang2ndAct
@mynucleus
Yes! The number on the left is your absolute risk, or your individual chance for type 2 diabetes based on your BMI, common DNA variants, and sex.
The number on the right is the average risk a female with your BMI has for type 2 diabetes, without accounting for DNA.
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Take familial hypercholesterolemia, a genetic condition that results in a 20-fold higher risk for heart disease.
The signs of the disease are so common that almost 90% of people with the disease don’t know they have it.
Risks like that are why we created Nucleus Premium.
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@itschristianxx
A crucial question! Other consumer genetics companies usually look at less than 0.1% of your DNA.
Our whole-genome sequencing technology looks at nearly all your DNA for a far more complete picture of your risks.
Learn more:
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@ayushaadijain
@alexisohanian
Thanks for sharing! Let us know what you think when your results come in 🙌
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A huge thank-you to our early members and everyone who has shared their results so far! Got your reports? Let us know what you think.
Want Premium? Preorder your kit now to be part of our summer batch:
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