Hugo Tejeda
@NeuroTejeda
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Neuroscientist. Views are my own.
Maryland, USA
Joined January 2017
Happy to share the latest preprint from the lab. Work examining the role of somatostatin neuropeptide transmission in the PFC in regulating associative learning underlying discrimination between salient and neutral outcomes. Led by @Miigii13
https://t.co/n1jniU2EYg
biorxiv.org
The prefrontal cortex (PFC) is essential for top-down control of affect and its dysfunction is implicated in many psychiatric disorders. Inhibitory interneurons expressing somatostatin have been...
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for anyone interested in the amygdala and risky decision-making, check out our new preprint: https://t.co/sRuIdwv4XX amygdala neurons track reward-seeking actions, and punishment risk dramatically alters this function. lots of other (BLA-accumbens!) data included.
biorxiv.org
Modifying behavior in response to changing environmental conditions is a crucial adaptive function. This capacity is exemplified when animals curtail pursuit of a valued outcome that risks being...
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I thought we would never work on gamma oscillations again but I was wrong! So happy to see this out in @Nature, truly an epic project spearheaded by @QuentinPerreno1. Gamma isn't always an oscillation, but it's critical for sensory encoding and perceptual performance. @YaleNeuro
(1/8) My latest study is out in @Nature ! Kudos to coauthors especially @jess_cardin and to @KavliAtYale and @WuTsaiYale for support. We find that gamma power in mouse visual cortex is caused by brief events supporting visual processing
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check out the latest work from Ken Ishii examining brain wide responses to opioid and withdrawal states. https://t.co/LI3K16enP6
biorxiv.org
How opioid exposure and withdrawal states shape brain activity at the systems and circuit level remains poorly understood. Here, we use whole-brain, cellular-resolution c-Fos mapping to define...
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One Mind is thrilled to announce the recipients of the 2025 One Mind Rising Star Awards! 💫 ⭐️ Laura A. Berner, PhD - Advancing Brain-Based Treatments for Bulimia Nervosa ⭐️ Neir Eshel, MD, PhD - Uncovering How Brain Circuits Drive Motivation ⭐️ Annegret Falkner, PhD -
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Excellent write-up on some of our recent findings. @BBRFoundation Researchers Trace How Ketamine Acts on Specific Brain Circuits and Synapses to Relieve Anhedonia | Brain & Behavior Research Foundation
bbrfoundation.org
Researchers have published a highly detailed account of a mechanism through which ketamine, a rapid-acting antidepressant, alters plasticity, or the strength of connections between neurons, and in so...
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This speaks to the importance of cross-species research that is constantly forward & back-translated between the clinic & lab. The importance of animal models leading to unanticipated discoveries - even in the realm of human psychology - is invaluable, especially in #psychiatry🧠
New paper!🚨📝 Paper: https://t.co/0H5HAAgAS3 Press release: https://t.co/39y0TPgWGR How the 🧠 engages in change-of-mind decisions taps into cognitive biases that depend on sensitivity to sunk costs & regret - both of which may contribute to negative rumination…however🧵👇1/6
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GREAT NEWS! Our paper on dopamine signaling of valueless prediction errors is out in @ScienceAdvances! I found that striatal dopamine tracks cue-cue prediction errors in sensory preconditioning, which goes against model-free theories of dopamine function. https://t.co/Q91KwzURAC
science.org
Dopamine reflects prediction errors not only about reward but also about valueless stimuli, challenging many current theories.
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:Trends in Cognitive Sciences The interoceptive origin of reinforcement learning
cell.com
Rewards play a crucial role in sculpting all motivated behavior. Traditionally, research on reinforcement learning has centered on how rewards guide learning and decision-making. Here, we examine the...
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Our new paper in collaboration with Bill Carlezon and @ErikMusiek on the effects of pain on sleep architecture is now out at @npp_journal . Work done by the amazing @DominikaJBurek and @khairunisa_ibk
https://t.co/SayKICzBYp
nature.com
Neuropsychopharmacology - Inflammatory pain in mice induces light cycle-dependent effects on sleep architecture
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Unpacking the dynamic role of physical effort in shaping behavior Opinion by Boris Cheval (@chevalboris), Silvio Maltagliati (@Maltagliati_s), Florent Desplanques (@Flodsplqs), & Wanja Wolff (@WolffWanja) https://t.co/0PiInQoT2x
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A new study in mice uncovers a stress-sensing circuit that interacts with light to influence circadian outputs. The work offers a roadmap for exploring the circuits linking light, circadian/sleep, and stress-related psychiatric disorders. https://t.co/lJsbBx3C8L
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Our Lab @NIH sponsored work is out! https://t.co/wv3Bc3oUyZ 🥳Vasopressin (AVP) excites BNST neurons via oxytocin receptor (not V1aR or V1bR) 🔬AVP excites CRF- and OTR-BNST neurons 🧠AVP inputs from SCN & SON excite BNST via OTR 🐁OTR-BNST neurons reduce anxiety in male rats
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I am so proud of my partner @Dr_Paulevj for being such an inspirational force for good and science. Congrats on your tenure!
Today, I was awarded tenure at the National Institutes of Health (NIH)—the equivalent of becoming a tenured full professor at a major research university. I’m deeply grateful To God To my family To my mentors To every mentee #NIHTenure #ScienceIsService #Gratitude #WomenInSTEM
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Thrilled to see this come to life and to have been part of the journey since the very beginning. Huge congratulations to Pablo and Gilles on building such a nice story!
nature.com
Nature Neuroscience - This study demonstrates that high alcohol concentrations during binge drinking activate a small GABAergic neuronal ensemble in the medial orbitofrontal cortex, which...
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Dendritic inhibition terminates plateau potentials in CA1 pyramidal neurons First preprint from the lab! Wonderful team effort, lead by incredibly talented Lee Vaasjo (@LVaasjo) and Shawn Kotermanski https://t.co/7pJzkDHeFt
biorxiv.org
In CA1 pyramidal neurons (CA1-PYRs), plateau potentials control synaptic plasticity and the emergence of place cell identity. Here, we show that dendritic inhibition terminates plateaus in an...
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Nature Reviews Neuroscience Brain mechanisms underlying the inhibitory control of thought https://t.co/3xNIxttnWn
nature.com
Nature Reviews Neuroscience - The capacity to prevent unwanted thoughts is important for cognitive function and mental health. Anderson et al. describe insights into the neural mechanisms of the...
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Our paper on opioid receptor regulation of mPFC inhibitory microcircuits is out as an early release https://t.co/ntJe0dNTrv
@allichonmc @mejoffe ! More to come on these systems in opioid dependence 🧠
jneurosci.org
Aberrant signaling within cortical inhibitory microcircuits has been identified as a common signature of neuropsychiatric disorders. Interneuron (IN) activity is precisely regulated by neuromodulat...
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🧠 🍄 ⚡️🐭 Now published in @NatureNeuro … Psilocybin enhances fear extinction by reshaping retrosplenial cortex ensembles—suppressing fear neurons, recruiting extinction neurons + boosting plasticity to enable behavioral flexibility https://t.co/uFA4glnOq0
nature.com
Nature Neuroscience - Rogers et al. show that psilocybin enhances fear extinction, suppresses fear neurons and recruits extinction neurons in the retrosplenial cortex in mice, providing evidence...
Excited to present my first first-author preprint from the Corder lab, with @EAHellerPhD and @flybottleescape – Psilocybin-enhanced fear extinction linked to bidirectional modulation of cortical ensembles. https://t.co/RbaXjwk0bc 1/10
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Almost all neurons co-release peptides and small transmitters. Thrilled to share our latest research where new GRAB sensor promotes better understanding of the dynamics and molecular regulation between neuropeptide and neurotransmitter release in vivo. https://t.co/P7XPjjP46y
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