Nate Huebsch
@NateHuebsch
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St Louis, MO
Joined August 2018
Congrats to our newest PhD graduate, @ghiska_tan, who defended her PhD last week. Ghiska's work on tensional anisotropy sensing paved the way for some critical technical and scientific advances in the lab. Congrats Ghiska!
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We are excited for the excellent work Sydney is now doing with @JeffreyRMillman and for the new science that comes from Sydney's discovery.
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With this "polymer nanopatterning" approach, Sydney found that BOTH peptide density AND the proximity between cell adhesive and growth factor mimicking peptides drive cell fate decisions (here, MSC osteogenesis).
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In this work, Sydney studied how integrin-binding adhesive peptides and growth factor mimicking peptides work together to push cell fate decisions. Sydney used orthogonal chemistries to graft these unique peptide types to a common polymer.
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Congratulations to @sydneal_123 on publication of the main body of work from her PhD thesis, now out in the Journal of Biomedical Materials Research Part A! https://t.co/cLUOHU2q2M.
onlinelibrary.wiley.com
Growth factors enhance survival and integration of transplanted Mesenchymal Stromal Cells (MSC), but successful supplementation often requires supraphysiological growth factor doses, risking off-ta...
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Wonderful working with this great team! Congrats Farid, Dela, Yuan, Ghiska et al.!
Guy Genin of #WashUMEMS & Nate Huebsch of @WashUBME have gained new insights into fibrosis, a condition that leads to tissue scarring. By manipulating mechanical forces on cells, they’ve discovered how tension can control cell behavior & prevent fibrosis. https://t.co/YgbPWgbylR
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Congrats to @sydneal_123 on her successful thesis defense! Sydney didn't let the winter storm stand in her way of presenting her work on growth factor mimicking peptides and their effects on MSC differentiation in hydrogel culture earlier today.
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human intervertebral discs. We are excited to share this work and for potential application of these materials for regenerative medicine applications. Preprint here:
biorxiv.org
Human mesenchymal stem cells (MSCs) have demonstrated promise when delivered to damaged tissue or tissue defects for their cytokine secretion and inflammation modulation behaviors that can promote...
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These gels enhanced MSC survival and dampened interleukin-induced inflammatory cytokine production by the MSC. The secretome of MSC within the gels with the IGF-1 mimics greatly decreased inflammatory gene expression in primary nucleus pulposus cells isolated from degenerated
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Excited to share the preprint of our latest work by Xiaohong Tan in collaboration with @setton_lab. We developed synthetic extracellular matrix alginate gels that present hydrogel-bound peptide mimics of IGF-1.
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Some really elegant work.
A collaborative effort with @firstage5 on cardiac organoid design optimization and single-organoid analysis based on machine learning techniques. @SUBioInspired @SyracuseBmce @organoidscience Cell Reports Methods
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hypertrophic cardiomyopathy (Myosin Binding Protein C mutation) and associated defects in myofilament structure and calcium handling. https://t.co/ER3tvSRNNw. Congrats to Mimi and the rest of the team!
cell.com
Mechanobiology; Biological sciences; Tissue engineering; Stem cells research
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Excited to post our work, just accepted in iScience. Led by @mimi_guo6, our team used biomaterials to control the mechanical load that iPSC-derived heart muscles work against. Both mechanical load and 3D tissue environment proved essential to observe hypertrophy linked to
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@kehealy @wyssinstitute @GladstoneInst @WashUengineers @WashUBME @LoriSetton @JonSilva_StL @WashUCardiology @RentschlerLab @GuyGenin And finally a thanks to the wonderful team, past and present.
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@kehealy @wyssinstitute @GladstoneInst Also a tremendous thanks to my mentors @WashUengineers and @WashUBME including @LoriSetton, @JonSilva_StL and Jeanne Nerbonne @WashUCardiology , @RentschlerLab and @GuyGenin.
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Such a tremendous honor. Thank you to my mentors both before and at WashU, along with wonderful members of the team here. Special thanks to my mentors as a trainee, @kehealy, Dave Mooney @wyssinstitute, Bruce Conklin @GladstoneInst and many others.
Congratulations to our #WashUBME faculty on their promotions! 🟦@NateHuebsch to associate professor of biomedical engineering 🟦@JhaLabWashU to associate professor of biomedical engineering 🟦@husong to professor of biomedical engineering https://t.co/AwiIFjHoaB
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Consider joining this great team to advance OCT technology
We are looking for talented individuals eager to contribute to an exciting ARPA-H project, aimed at developing cutting-edge PIC-OCT systems ( https://t.co/WVvSkAdxjd). Multiple positions, including PM, post-doc, admin assist and grant specialist, are available for immediate start.
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Publication here, along with a very nice summary writeup from APL Bioengineering. Congrats Daniel and team! https://t.co/7DO5RdCPYi
https://t.co/zbPUXhF0fE
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Elongated tissues had enhanced function and expression of sodium channels and gap junctions compared to spheroids. We leveraged this to model the effects of a desmosome mutation that is linked to arrhythmogenic cardiomyopathy.
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Congrats to Daniel Simmons and rest of team for this work, now published in APL Bioengineering. Daniel used SLA 3D-printing assisted microfab technology to create PDMS-based molds with different shapes to control geometry of engineered heart tissue derived from iPSC.
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