Michael Giannetto
@MichaelGiannet1
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Astrocyte endfoot appreciator | PhD Candidate in Nedergaard Lab | University of Rochester Medical Center
Rochester, NY
Joined November 2012
Instead of a snarky review tearing others down (like some "colleagues" do), we gathered 24 PIs with different views to write a data-driven review on glymphatic–lymphatic connections and brain immunity, focused on open questions. It’s out now—hope you enjoy the read.
Resolving the mysteries of brain clearance and immune surveillance: Neuron
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Great article in Science about our study 🤗🧠🚿
science.org
Pulsating blood vessels push fluid into and out of the brains of slumbering mice
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Excited to have this work finally out… it addresses many controversies in the field and the take home message - if you are imaging your mouse keeping it in a particular head position, make sure to emphasize that because your data will be different from mouse images with another
Papadopoulos et al. @kipnislab @WUSTLmed present new findings on how lymphatic outflow pathways shape brain health, a critical frontier in brain-immune communication. https://t.co/K8ZKsOVe2E
@lcdsmyth
#Neuroimmunology #CSF #BrainHealth #Neuroinflammation
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Very happy to contribute to this article led by the brilliant @Peterarbork. Exciting and important modeling of osmotic gradients driving brain fluid flows. Read it now and enjoy the beautifully clear figures! Open access!
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From Division I swimmer to @URochester_SMD neuroscience graduate student Evan Newbold is studying the glymphatic system—the brain’s waste removal system. https://t.co/TnZxWWaCuy Read how his #URochesterResearch could pave the way for new therapeutic approaches using the
urmc.rochester.edu
Evan Newbold is a fifth-year neuroscience graduate student at the University of Rochester School of Medicine and Dentistry. He received his undergraduate degree in neuroscience from Lafayette College...
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Jon Stewart on election night: "We're all going to have to wake up tomorrow morning and work like hell to move the world to the place that we prefer it to be." #DailyShow
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Our new review in @NeuroCellPress with @neurobenjamin and @Drieu_Antoine on why you need to keep your brain clean so it ages slowly and well 😉 || Waste clearance shapes aging brain health
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📰Excited to share our latest work just published in @NatureComms Endothelial Piezo1 channel mediates mechano-feedback control of brain blood flow https://t.co/aGJPN5bbUZ 🧵
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1/4 We are thrilled to announce that our 🌍 collaboration has resulted in a paper in @_JCBFM. @Gazz4_Science @CathFoster_ @BradASutherland @UTAS_ @SeattleChildrens @uni_copenhagen
https://t.co/Wzp9CHnXtO
journals.sagepub.com
The close spatial relationship between microglia and cerebral blood vessels implicates microglia in vascular development, homeostasis and disease. In this study...
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New paper from the Nedergaard lab: glymphatic clearance is increased during sleep and decreased during wakefulness
Why sleep is important!
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OUT NOW from Udaysankar Chockanathan & Krishnan Padmanabhan @Neurocircuitlab Differential disruptions in population coding along the dorsal-ventral axis of CA1 in the APP/PS1 mouse model of Aβ pathology https://t.co/AAmLIGTOiV
#URochesterResearch @URNeuroscience
journals.plos.org
Author summary Patients with Alzheimer’s disease (AD) experience an array of cognitive deficits, such as memory loss and executive dysfunction, as well as behavioral symptoms, such as agitation and...
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We are excited to share a new study from our lab, published today in @ScienceMagazine. Using a genetically encoded bioluminescence protein we measured cerebral oxygen dynamics in the awake mouse brain @mrfelix @temp2spec a thread: https://t.co/RGl01BHbJD
science.org
GeNL bioluminescence imaging detects the existence of spontaneous transient “hypoxic pockets” in awake behaving mice.
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New paper! Our results suggest that small and large molecules might be cleared from the brain via partly different mechanisms where clearance of large molecules seems to be influenced by AQP4 polarization to the endfeet and animal age within adult range. https://t.co/046vSkmPHE
link.springer.com
Fluids and Barriers of the CNS - Waste from the brain has been shown to be cleared via the perivascular spaces through the so-called glymphatic system. According to this model the cerebrospinal...
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We are hiring! Glialab is looking for 1 PhD student to work on vascular dynamics in sleep, 1 PhD student to analyze imaging/ephys/behavior data and 1 PostDoc to work on gliovascular interface/vasomotion/sleep. If this sounds interesting - contact us! Please spread the word!
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We utilized a broad range of techniques including fluorescent tracers, immunohistochemistry, and 9.4T MRI. Thank you to all coauthors who helped collect this exciting data! Can't find everyone on twitter so ➡️@NedergaardLab
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🚨New paper is out now!🚨 Acute inhibition of AQP4🚫 reduces brain water movement and glymphatic flow. Further confirmation that AQP4 is vital to glymphatic flow and a therapeutic target for brain edema🧠.
onlinelibrary.wiley.com
The aquaporin-4 inhibitor AER-271 acutely decreases glymphatic flow similar to glymphatic decrease with genetic deletion of aquaporin-4. AER-271 prevents ADC changes in WT mice. Glymphatic inhibiti...
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🔥🔥🔥I have made another #VR #sciencevideo! 🥽👨🔬 This time I explore the #immunecells of the #MICrONS dataset that are a part of my BiorXiv preprint on the #Ultrastructure of the #brain #waste cleareance pathway 🧠🗑️🧹🛣️ https://t.co/W2uR5MI8YM
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If you want to join our monthly pain journal club organized by PhD student @TinaEsmail please send her a DM. (FB)
Amazing presentantion by @KhannaLabNYU at our interinstitutional pain JC. Are you a pain enthusiast and would like an invite to our monthly meetings? Let me know!
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@drew_lab_nvc, @Kevin_L_Turner, @NanyinZhang, @Qingguang_Zhang show that sleep-related vascular changes dominate over sensory-evoked changes with a combination of optical imaging, electrophysiology, and BOLD fMRI in unanesthetized neonatal mice. https://t.co/GY2vIvAHyw
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