Mario Leutert
@MarioLeutert
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#proteomics | #Signaling | #PTMs | #phospho | #SystemsBiology | #TeamMassSpec
Zurich, Switzerland
Joined May 2019
Excited to share our newest #preprint: Multidimensional proteomics identifies molecular trajectories of cellular aging and rejuvenation. A great project with the @juditvr @DunhamLab @mkaeberlein teams! 📄Read: https://t.co/i78BXLFrdL 💾Explore: https://t.co/ZVlUGMAVnn 1/9
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Feeling pretty psyched to see a major work from my postdoc now published, this time in @embojournal We examine the fitness cost of spurious phosphorylation, with major additions over the 2023 preprint: https://t.co/354VPJWLTC My tweetorial is below (1/n)
embopress.org
imageimageHow do off-target interactions between proteins inside crowded cells affect cellular fitness? Expression of human tyrosine kinases in yeast, which lacks general tyrosine phosphorylation,...
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The #SignallingAlliance seminar series continues today at 3pk UK, 4pm CET. Today we have talks by @MarioLeutert and @fabfrohlich Free to watch at https://t.co/mlSMDCXWJP
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This Thursday! Note the slight change of plans with Mario Leutert representing the @juditvr group.Looking forward to two exciting #SignallingAlliance talks!
3 weeks to go till our next #SignallingAlliance seminar! Mark your calendars and join us! Feb 1st, 3-4pm UK time! We will be featuring @fabfrohlich from @TheCrick (complexity of signalling systems) and @juditvr from @uwgenome (proteomics and signalling)!
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#IBFG_External_Seminar | Join us on January 19th for a seminar entitled "Deciphering Regulatory Protein Networks in Aging and Stress Signaling" by @MarioLeutert, a researcher from @IMSB_ETH. 🔑Free Access ⌚️12.30 pm 📍 IBFG Conference Room More info👇
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Ever wondered how the #proteomes of different #synapse types vary? 🧠Our latest study from @erin_schuman lab published at @CellCellPress reveals the #diversity across 18 distinct synapse types👇@MpiBrain 💰@snsf_ch ⚖️#TeamMassSpec 💾 https://t.co/DaqUejxLjy
cell.com
Systematic analysis unveils the diversity of synaptic proteomes and their organization, showcasing ∼1,800 unique synapse-enriched proteins, common synaptic modules, and specialized proteomic hotspots...
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For a breakdown of the study check out the news and views article: https://t.co/dgwePfhpTz and the previous tweetorial:
Excited to share our work on high-dimensional #phosphoproteomics in yeast exposed to >100 environmental and chemical perturbations. This is one of the largest and most systematic perturbation-phosphorylation resources for any species. #TeamMassSpec (1/8)
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Very happy to share our extensive and systematic Phosphoproteomic Stress Signaling Atlas that is now published @NatureSMB: https://t.co/lEseL8nwB5 Thanks to the @juditvr lab and co-autors @AnthonyBarente , Noelle Fukuda & @RRodriguezMias! #proteomics #signaling #TeamMassSpec /1
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There are a number of open questions in cell signalling that require a systems level view. Our Signalling Alliance webinar series will pair experimental and computational groups exploring these questions. Join us online.
I am pleased to launch the #SignallingAlliance zoom #Seminar series! First up @roserventotormo (#singlecell communications) and @KrishnaswamyLab (#AI) on 02/11 3-4pm UK time. Details on the alliance and seminars can be found on this poster and this link: https://t.co/bbNGy6SU3x
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Thrilled to share our work profiling Ale yeast protein dynamics across fermentation and serial repitching! https://t.co/Lu2CL80Lxd
@DunhamLab @edward_marcotte @LiveOakBrewing #BeerYeast #SystemsBiology #Proteomics Sneek Peak thread🧵 below
biorxiv.org
Studying the genetic and molecular characteristics of brewing yeast strains is crucial for understanding their domestication history and adaptations accumulated over time in fermentation environmen...
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We are happy to present our workflow DQGlyco enabling the in-depth quantification of glycoproteome dynamics. In total, we characterize > 150,000 glycoforms in the mouse brain. https://t.co/hRDnvzORkS
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Out now in @eLife: We explore how genetics and environment rewire muscle insulin signalling Featured here: https://t.co/s9rTrI9AMU Available here: https://t.co/i1Avv6tbtG A thread
elifesciences.org
An analysis of insulin-controlled proteins in the skeletal muscle of genetically distinct mice sheds light on the interplay between genes and diet in type 2 diabetes.
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How many different protein shapes are there in 200 million predicted AlphaFold structures? In a joint project with @thesteinegger we (@ibarrioh, @jgyyy15 et al) clustered these into around 2 million groups to study their novelty and evolution
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I am truly excited to share one of the major works to emerge from my postdoc, now on bioRxiv: https://t.co/Y2YHSCM7Rx We explore the role of differential 'substrate quality' on the phosphorylation of kinase targets, using as our case study the master kinase CK2 (1/n).
biorxiv.org
Most biological processes are regulated by peptide-recognition modules (PRMs) that bind to short linear motifs (SLiMs). Such interactions are rapidly reversible and often occur at low affinity. The...
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We are looking for a #PhD candidate! Are you interested in #chromatin and want to combine high-throughput methods & molecular biology to understand how histone #PTMs regulate chromatin functions using #yeast? 👩🔬🧑🔬🧫🧬 Contact us 👇Please spread the word!
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Excited to attend #ASMS2023 and present our approach to study cellular aging using multidimensional proteomics:
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The method might be cheap, but the data is priceless.
Here's what happens when you start working with a postdoc & scientist too cheap to buy reagents: @MarioLeutert @RRodriguezMias Checkout our automated and cost effective phosphotyrosine enrichment protocol now in JPR! @juditvr Villen Lab, UW https://t.co/ELOeavbuTq
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Our Yeast 5k Proteome Project is now published in Cell. We measured proteome profiles for almost 5,000 single knock-out yeast strains. We show what drives protein changes and how this resource can be used for functional annotation of genes and proteins. https://t.co/TPC8qQqu7a
cell.com
By combining functional genomics with proteomics, molecular phenotypes in the yeast Saccharomyces cerevisiae can be assigned at genome scale, and systems-level insights reveal principles of how gene...
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Do you want to see how #AlphaFold2 can be applied to study protein-protein interactions? Join us for a new #FGCZseminar where @pedrobeltrao will show its potential and limitations. April 25th, 16:00-17:00 Registration required Apero will follow #proteomics, #interactionproteomics
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This was an amazing team effort between the labs of @juditvr , @DunhamLab , @mkaeberlein with contributions from Joe Armstrong, @AnjaOllodart , Kyle Hess, Michael Muir and @RRodriguezMias . 9/9
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