I’m very excited to share our latest work diving into how axons survive injury and fuel their regeneration. This work is a collaboration between @LabMoons and @FarrowLab, with the invaluable help of @StevenBergmans @vandyckannelies @GroefLies. Check it out in @JCellBiol!

📢 New paper out in Nature! The Hoekstra lab at Harvard and Farrow lab at NERF reveal how a brain switch is tuned by evolution to control freezing vs fleeing in two sister species of deer mice. 👏 Huge congratulations to the entire team https://t.co/vD8uytulUh

🚨🚨 Paper alert! Check our latest work published in @FrontNeurosci and find out how different species respond to optic nerve injury!! https://t.co/X0xtvFwHl4 🚨🚨 @JulieDeSchutter @AnyiZhang2 @PieterJanSerneels @LucaMasin @StevenBergmans

🚨Preprint alert🚨 Joint effort by @LabMoons on elucidating retinal ganglion cell resilience to optic nerve injury across vertebrate species. Check it out! @JulieDeSchutter @AnyiZhang2 @StevenBergmans

How can vertebrate neurons fuel the regeneration of their injured axons? Check out our new preprint to find out! Great work from @AnyiZhang2 @StevenBergmans @vandyckannelies @LabMoons

🚨 We’re hiring 🚨 Interested in glial biology, retina ageing and killifish? We will soon be advertising a postdoc and technician position in my laboratory. Please get in touch if interested. Picture of our new glial reporter transgenic killifish. Courtesy of @ChiKuoHimself

Check out our preprint using imaging-omics to characterize the #OrganelleSignature - the morphology interactions & distribution of #ER❤️ #Lysosomes🩵 #Mitochondria💚 #Peroxisomes🧡 #Golgi💛 & #LipidDroplets🩷 - of live #neurons and #astrocytes! https://t.co/RmGRnut5my 🧵1/11

Image: regenerating Pten & Socs3-deficient axons are characterized by enhanced localization of glycolytic enzymes. @LucaMasin, @LabMoons @KU_Leuven provide new insights into the metabolic underpinnings of axonal regeneration. https://t.co/mBX0Vu1r7B #CellMetabolism #Neuroscience

Local #glycolysis supports injury-induced axonal regeneration, say Luca Masin @LucaMasin, @StevenBergmans, @vandyckannelies, @FarrowLab, @GroefLies, and Lieve Moons @LabMoons @KU_Leuven: https://t.co/bWAB1YeYd7 #Metabolism #CellMetabolism #Neuroscience

Santos et al. show that a local energetic coupling between glycolysis and actomyosin is necessary for axonal retraction in response to repulsive cues: https://t.co/M3VUiyRt4G 📙 In our Cellular Neurobiology collection: https://t.co/Nf9gZboZbu #SfN24 #Neuroscience

Together, these observations reveal that glycolytic ATP, combined with sustained mitochondrial transport, is essential for injury-induced axonal regrowth, providing new insights into the metabolic underpinnings of axonal regeneration

Downregulation of glycolysis via galactose treatment completely abolished the enhanced regeneration phenotype of Pten and Socs3 co-deleted axons and impaired their ability to produce ATP

We found that while wild-type axons relied on mitochondrial metabolism, after injury, in the absence of Pten and Socs3, energy production was demonstrated to be supported by local glycolysis

Using retinal cultures in a multicompartment microfluidic device, we observed increased regrowth and enhanced mitochondrial trafficking in the axons of retinal ganglion cells with the co-deletion of Pten and Socs3

We found that regeneration-competent retinal ganglion cells co-deleted for Pten and Socs3 (cdKO) promptly undergo a switch in the expression of metabolism-related genes after optic nerve crush injury, upregulating genes involved in glycolysis and lactate production

The cell adhesion molecule protocadherin10 is linked to autism in humans. Together with the @SeuntjensLab, we now show that mice with protocadherin10-deficient interneurons display alterations in amygdala development and socio-affective communication: https://t.co/b1oXkcAAc8

Neuronal activity inhibits axonal mitochondrial transport in a region-specific manner https://t.co/JvwbLgGifr #biorxiv_neursci

My final paper as a PhD student has officially been published in @AgingCell. Big thanks to all the authors involved, especially @NCLNoel, @LucaMasin, @phruzycki, @Brian_S_Clark and @MacDonald_Lab for the enormous help while producing this wonderful paper! Next stop? PhD defence

Excited to share our new preprint showing ER-mitochondria contact sites as apical nexus of lipid-peroxidation driving ferroptosis. Kudos to our @SassanoLivia & thx to our collaborators @LMCSLeuven, #KaganLab and @LabScorrano #ferroptosis #contactsites #ER https://t.co/Vme4qkBfdw

How does the brain of the fast aging #killifish develop? Find out in our latest preprint! 🐟🧠