Oct 22 2024, “the totality of the data supports the potential of HGF modulation for the treatment of neurodegenerative diseases” Javier San Martin CMO Nov 7 “Athira has paused further development of fosgonimeton…and are exploring partnering options” What changed in two weeks?

@PAULJLAMONT @smead2 @seb_walsh @pash22 @LogarithmicDis @nvillain_alz @EWidera @MemoryDoc @LTCShop @Jeff_Browndyke @LonSchneiderMD @ProfRobHoward @MadhavThambiset @KasperKepp @RenegadeSynapse @DanielErsk1ne @dr_shibley @AlbertoEspay @PhilAlz @_michael_scholl @VincentPlanche @StefanoSensi14 @Gill_Livingston @DrTFromKC @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @howard_gleckman @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @EmmyBetz @DrJoRyan @MaggieAime @OskarHansson9 @DavidJonesBrain @JenniKBurton @StormNewton @alzforum "Gantenerumab significantly increased CSF Aβ42 compared to placebo at year 4 (Supplementary Fig. 5, P < 0.001)" https://t.co/VZWnF5fSgS

On Wednesday at 415p in #Philadelphia the @TheLancet commission on dementia diagnosis prevention and treatment will present its 3rd report at the #AAIC24 #AAIC2024 beginning of there or be square Or you can see Arsenal play Liverpool at Lincoln Field in Philadelphia.

Tip of the iceberg. This kind of fraud tends to pay as it gets the molecule through pre- & clinical tox & into phase 2/3 trials that could easily be positive on an outcome by chance alone, or hook and crook. Anyway, Cassava will have him pardoned on January 20 if they pay up.

Many rushed to shame @DukeU for what happened today, at the Graduation ceremony - a bunch of pro-palestine students booed Jerry Seinfeld and left before his speech. I know from personal sources that Duke handled exemplary the whole anti-jewish ordeal. There were no encampments,

Wow. Joe Scarborough just decimated Donald Trump, the Republican Party, and Fox News in under 3 minutes for constantly hating America. Blown away by how well said this was. Certainly worth a watch👇

Lilly $LLY shareholders? That’s vanguard, fidelity, black rock, state street, jpm, anyone with a 401(k), pretty much all of us. I should start acting like an owner? FDA! Free donanemab! From coast to coast, ocean to ocean, river to sea?

Sorry, this is disease modifying (if you thought the graph was of an antibody). As “everyone knows” cholinesterase inhibitors are symptomatic, then this donepezil graph must be showing a symptomatic effect. It just can’t be otherwise.

The only reason for the divergence at all was the zeroing out of the baseline with multiple covariate adjustments. As both curves started at the same value, definitionally, they had to diverge.

Looks like open label extension of p3 lecanemab’s low tau subset. I’m sure there’s disease modification there somewhere.

Looks like extension of phase 2 lecanemab withdrawal period and phase 3’s open label extension.

@Gill_Livingston @JuandoGispert @ResearchGate @TheLancet @ProfRobHoward @Naaheed_Mukadam @LonSchneiderMD Thanks for communicating this. Since we have cited this paper, I got several notifications from them. Last one was this past Friday. Had no idea the retraction badge was a mistake.

@TaliaIsaacs @Gill_Livingston @ResearchGate @TheLancet @ProfRobHoward @Naaheed_Mukadam @researchGate @RGsupport should retract their made-up retraction. least they could do. Maybe @ElsevierConnect @ElsevierNews @TheLancet should sue.😀

Yup, we’ve always suspected that Alzheimer pathology is mainly a plumbing problem — waste management.

Always worth listening to what @LonSchneiderMD has to say about the interpretation of clinical trial data.

@Gill_Livingston @ResearchGate @TheLancet @ProfRobHoward @Naaheed_Mukadam @LonSchneiderMD “They have retracted the retraction badge but say they can't tell those emailed despite our reputational damage.” Can’t or won’t?

@Gill_Livingston @ResearchGate @TheLancet @ProfRobHoward @Naaheed_Mukadam @LonSchneiderMD Sorry about this Gill. Have shared. Best wishes.

@barttels2 @MadhavThambiset @EWidera @smead2 @ajlees @ProfRobHoward @MemoryDoc @dr_shibley @LonSchneiderMD @seb_walsh @_michael_scholl @VincentPlanche @StefanoSensi14 @AlbertoEspay @nvillain_alz @KasperKepp @PhilAlz @Gill_Livingston @DrTFromKC @jfballenger @jasonkarlawish @JamesRuFletcher @AdamMBrickman @ManlyEpic @SFAckley @FortuneMagazine @TIME @ErinMPrater @TimeMagazineRS @FT @hannahkuchler @CTADconference @NIH @alzassociation @howard_gleckman @AmerGeriatrics @kathy_y_liu @r_merrick @nlundebjerg @NathanielChinMD @US_FDA @NICEComms @RaymondKoopmans @MaastrichtU @Kariem_Ezzat @DrBenUnderwood1 @NHSEngland Not sure what @ResearchGate is upto, but they have erroneously retracted @Gill_Livingston et al's @TheLancet paper on dementia ⬇️ https://t.co/Y09UjyvfEE

@@ResearchGate wrongly emailed out a retraction of our @TheLancet paper. They have retracted the retraction badge but say they can't tell those emailed despite our reputational damage. Please tell people. @ProfRobHoward @Naaheed_Mukadam @LonSchneiderMD

Here’s a fun one. Poop out after 18 months in low tau subset?