LiccardiLab
@LiccardiLab
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Cell death, Inflammation & Genome stability in Tissue & Cellular homeoastasis. Pi @Giammy_L @BCCologne #inflammation #celldeath #cellcycle #immunity #cancer
Cologne, Germany
Joined September 2021
Reading the comments both under this post and under Nature’s obituary of Watson, it is impossible not to see how deeply ingrained sexism and abuse of power still are in science and beyond. Rosalind Franklin’s case was not only a tragedy of erasure, but an example of how authority
Getting Rosalind Franklin’s story right is crucial, because she has become a role model for women going into science https://t.co/wR8fBl5cNJ
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A paper for #Halloween. Equally thrilled to have this work out in lightning speed with @Giammy_L ! #Ferroptosis #celldeath
Thrilled to share our latest paper in Cell Death Discovery! 👉 https://t.co/Ohd2eYMyqE Together with my fantastic co-senior and co-corresponding author @vonKarstedtLab , we uncovered that the BTK inhibitor ibrutinib has a previously unrecognized role in disrupting redox balance
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Fantastic work by @vonKarstedtLab and @LiccardiLab Ibrutinib sensitises to Ferroptosis #dlbcl #ferroptosis #btk #ibrutinib
https://t.co/n6lCsnmFmP
nature.com
Cell Death Discovery - Redox destabilization by ibrutinib promotes ferroptosis in diffuse large B-cell lymphoma (DLBCL)
Thrilled to share our latest paper in Cell Death Discovery! 👉 https://t.co/Ohd2eYMyqE Together with my fantastic co-senior and co-corresponding author @vonKarstedtLab , we uncovered that the BTK inhibitor ibrutinib has a previously unrecognized role in disrupting redox balance
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🚀 Thrilled! Our Nature paper was highlighted in @MolecularCell! ✨ STING, known for innate immunity, regulates TNFR1 & ZBP1 necroptotic checkpoints, driving inflammatory cell death. Blocking necroptosis ameliorates SAVI pathology. 🙌 https://t.co/JheHN3SwlD
#STING #Necroptosis
cell.com
In a recent Nature paper, Kelepouras et al. uncover how STING licenses ZBP1-driven necroptosis through transcriptional priming and Z-nucleic acid amplification, revealing a pathogenic circuit in SAVI...
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Our research is featured on national news! Awareness and information are essential to empower innovation and translate scientific discoveries into real benefits for patients. 🧬🎥 #ScienceCommunication #Research #Innovation #CancerResearch
I’m deeply grateful to @WDR_News for the opportunity to share my scientific journey and perspectives as part of the CANTAR (CANcer TARgeting) network, funded by Ministry of Culture and Science of the State of North Rhine-Westphalia (MKW NRW) @MKW_NRW. Public communication is
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🧬 New in Nature: Host cell Z-RNAs activate ZBP1 during virus infections https://t.co/60UjAOBA2H Biggest congratulations to Sid Balachandran and his lab for yet another amazing piece of work on Z-RNA/ZBP1. Turns out, it all starts with the DoTT. #immunology #celldeath #ZBP1 #ZRNA
nature.com
Nature - Cellular Z-RNAs generated during active virus infections are bona fide ZBP1 ligands, and position ZBP1-activated cell death as a host response to counter viral disruption of the cellular...
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Thank you @fattoquotidiano for covering our rcent work in Nature. https://t.co/ZZPcLLr3nI Full article:
ilfattoquotidiano.it
Uno studio congiunto tra l'Università di Colonia e il Bambino Gesù ha scoperto il ruolo della proteina STING nelle malattie autoinfiammatorie pediatriche.
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The STING of death continues! Thanks to @NatRevRheumatol ( https://t.co/8E2bSNFP2u) for highlighting our recent @Nature ( https://t.co/ojysOBiGiS) paper showcasing cell death as a therapeutic avenue in autoimmunity & autoinflammation, (SAVI syndrome). (The image below is our own)
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Fantastic team work! Lets keep the conversation going.
The STING of death continues! Thanks to @NatRevRheumatol ( https://t.co/8E2bSNFP2u) for highlighting our recent @Nature ( https://t.co/ojysOBiGiS) paper showcasing cell death as a therapeutic avenue in autoimmunity & autoinflammation, (SAVI syndrome). (The image below is our own)
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Quando le cellule si auto-distruggono: scoperto il meccanismo che scatena una #malattiarara infantile. I risultati dello studio congiunto tra l'Ospedale e l'Università @UniCologne
https://t.co/7SQekID3ac
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I am beyond excited and incredibly proud to share that our work is now out in @Nature . https://t.co/DaPQSUAdh2
nature.com
Nature - STING-activation-induced necroptosis (STAIN) is a central pathogenic mechanism in both caspase-8-deficient inflammation and STING-associated vasculopathy with onset in infancy.
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A truly inspiring and insightful lecture by Prof. @HallekMichael today on the future of oncological therapies. Groundbreaking advances meet pressing questions of affordability. Thank you for a thought-provoking evening! #Oncology #MedicalInnovation
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Promising new treatment approach for severe COVID-19! Clinical trial with Fas ligand blocker shows faster recovery & reduced mortality. Approach targets immune overreaction, potentially effective against future viruses too. #COVID19 #Science #PublicHealth
https://t.co/uPC967yxNJ
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What a talk on fantastic work spearheaded by our own @julia_saggau discussing the regulation of LUBAC by DUBs. @Walczak_Lab @LiccardiLab Happening at @Fusion_Conf #ubiqui24
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What a fantastic couple days with @pseudokinase James Murphy. It was great to have you in Köln. Amazing discussions, fantastic science and of course a pleasure to catch up. Till next time .
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This week we had the amazing pleasure to have @Linkermann_Lab presenting some of his fantastic work. An absolute stimulating visit with an expert, a collegue and friend!
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Staring at death! Have a look at our first publication where we provide a protocol for a robust and reproducible in situ detection of pMLKL-s345 in vivo!
Incredibly proud of our first paper in @cddpress on pMLKL-s345 . Congrats @c_kelep for driving this project. BIG Thank you to all our collaborators @ale_annibaldi81 @Linkermann_Lab @Walczak_Lab @PardoGalvez_Lab for your incredible support and input.
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Thank you @ina_huppertz for your kind invitation to Cologne @MPIAGE and the stimulating discussions also with @Walczak_Lab @RonJachimowicz @TheVilchezLab @Giammy_L and other X-less (ubiquitin) people like Kay Hoffman. Great to also see former colleages from @IMPRS_LM and @mpimoph
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Looking forward to present our work and participate to this fantastic meeting that I am sure will be inspiring and stimulating. Registration and abstract submission are still open. Looking forward to see you in Lisbon #ubiquitin
@Giammy_L we're looking forward to your presentation at #Ubiq24 in July! 🇵🇹 Please RT to let your followers know you'll be speaking & our talk submission deadline has been extended (01 April 2024) if they'd like to join us! Find out more: https://t.co/cx6NOQo0Ag
@LiccardiLab
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