Heard of Reissner’s fiber? No? You’re not alone! This bizarre brain structure forms during embryogenesis from SCO-spodin protein & extends from subcommissural organ to spinal cord
NEW:
@Huixin_BJ
et al show developmental importance of SCO-spondin in mice
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We explored the enigmatic Reissner's fiber by focusing on the SCO-spondin protein (SSPO). Using a novel crispr Sspo knockout mouse model, we delved into how lacking SSPO and the Reissner fiber impacts brain and spinal development. 2/6
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Surprisingly, our Sspo knockout mice showed smaller brain ventricle sizes via MRI compared to normal, & not due to a smaller brain phenotype. This suggests a complex role of SSPO in cerebrospinal fluid (CSF) regulation and brain development. 3/6
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Sspo−/− mice exhibited subtle yet notable changes in spinal geometry, specifically in the thoracic region. Our custom analysis pipeline revealed that these changes become more pronounced with age, underscoring the complexity of spinal morphogenesis in mice. 4/6
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Our study raises ?s about SSPO's role in brain development. 🧠Small ventricles in Sspo−/−
mice suggest changes in CSF dynamics, potentially influenced by SSPO's interactions w/ CSF proteins. This may affect CSF osmolarity, secretion, and flow w/ long-term consequences 5/6
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Shoutout to collaborators for innovative work developing a morphometric analysis pipeline using 3D modeling, allowing ID of spinal geometry changes that traditional techniques may miss. Guillaume Dugué,
@CantautBelarifY
, François‑Xavier Lejeune, Suhasini Gupta, and
@ClaireWyart
!
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@LehtinenLab
@slewzeus
@Huixin_BJ
@BioMedCentral
@FMKirbyNeuro
@BostonChildrens
@harvardbrainsci
Well done!
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@LehtinenLab
@Huixin_BJ
@BioMedCentral
@FMKirbyNeuro
@BostonChildrens
@harvardbrainsci
Very cool! Congratulations!
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