New review from @Lab_Coleman Axon Biology in ALS: Mechanisms of Axon Degeneration and Prospects for Therapy.
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Is ALS a ‘dying back’ or dying forward disease? What do we mean by this, how can we tell, does it happen and what does (and doesn’t!) this tell us?
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In which subcellular compartment/s does pathogenesis begin? Does this question even have a single answer or could it differ from patient to patient?
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What is the evidence for a role of SARM1 in ALS, how can it be activated and what else do we need to know?
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What else can kill axons in ALS and how can we stop it? Interested to have further discussion if there are other questions/other views out there!
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