✅ Crohn’s patients with mod- to severe disease who had FAILED therapy w biologicals ✅ PLACEBO resulted in clinical remission in 30%, compared to 50% with upadacitinib ✅ 50% of patients on upadacitinib failed ✅ upadacitinib is an option, no panacea Tweet added by Klaus Mönkemüller, MD, PhD @KMonkemuller

Klaus Mönkemüller, MD, PhD

1 year

✅ Crohn’s patients with mod- to severe disease who had FAILED therapy w biologicals ✅ PLACEBO resulted in clinical remission in 30%, compared to 50% with upadacitinib ✅ 50% of patients on upadacitinib failed ✅ upadacitinib is an option, no panacea

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Thomas Balanis

@ThomasBalanis

1 year

@KMonkemuller I am very impressed, though, with all the studies until now that the placebo groups have so high rates of clinical remission.. 30% clinical remission?? How do you explain this? @KMonkemuller

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Klaus Mönkemüller, MD, PhD

@KMonkemuller

1 year

@ThomasBalanis ➡️ Clinical endpoints to „soft“?, remission was defined as 30% less diarrhea ➡️ the 🧠 is strong-influences microbiome ➡️ what I don’t like is that in the maintenance group they compared 💊 responders to placebo (non-responders?). They should have compared to placebo responders

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katsam_rx

@KatSam_RX

1 year

@KMonkemuller Thanks for your clear and honest thoughts on upadacitinib. Would you be willing to review a short newsletter (30 text lines) about upadacitinib and mod--severe Crohn's?

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