Jean-Baptiste Micol
@JB_Micol
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MD/PhD @GustaveRoussy, Hematologist #AML #Therapy related myeloid neoplasm #Clonal hematopoiesis #CHIP
Paris, France
Joined March 2023
📣 We are excited to announce the first scientific day on liquid biopsy, organized by @GustaveRoussy and the @PrismCenter, taking place on June 11, 2025, in Paris! 🧬🔬 🔗 More information & registration:
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Delighted to share our work on clonal hematopoiesis #CH out now in @NatureGenet. We revealed ancestry as a risk factor for CH 🧵 @ASTRAZENECAUK @Cambridge_Uni
https://t.co/4Raaujn3In
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Cette nouvelle étape reflète l'engagement de @GustaveRoussy à toujours placer nos #patients au coeur de nos priorités et à renforcer notre mission de #soins et d'#innovation pour tous. Le progrès, c'est aussi rendre la santé plus accessible !
La station de métro Villejuif - Gustave Roussy de la @Ligne14_RATP a ouvert ses portes aujourd'hui ! Plus qu'une #station, c'est un lien direct qui rapproche des milliers de personnes des soins, de l'innovation et de la recherche.
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Cancer survivors are growing in number. In the US, nearly half of survivors have lived 10 or more years after diagnosis, while 19% have lived 20 or more years. The prevalence of long-term survivors is expected to increase through 2040. https://t.co/nzjl6sIFE4
#CancerSurvivorship
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Read this study by Dawi et al regarding tumor fraction liquid biopsy performed for tumor burden assessment and how well it correlated with total tumor volume at CT. https://t.co/a4he8s9RJq
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Huge work of @GustaveRoussy Radiology Department and MTB: "Liquid Biopsy versus CT: Comparison of Tumor Burden Quantification in 1065 Patients with Metastases". 📌Article: https://t.co/JzTIoNQn2k 📌Editorial: https://t.co/Tlyf4xKjSc
Read this study by Dawi et al regarding tumor fraction liquid biopsy performed for tumor burden assessment and how well it correlated with total tumor volume at CT. https://t.co/a4he8s9RJq
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A nice commentary in this issue of @BloodJournal for our paper looking at the role of #ClonalHematopoiesis in #TBD from @Chris_R_Reilly and @myllymaki_mikko - a somatic symphony; telomeres and CH! https://t.co/Ir7UjkieWq
@fergutierrezro1 @SharonSavageMD
https://t.co/Ir7UjkieWq
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Congrats to our PhD student, @Debureaux_PE and all co-authors for this collaborative work performed with Saint Louis, Cochin, Pitié Salpétrière, Lille, Necker, Mondor and Avicenne hospital on Inflammatory Waldenstrom and Clonal hematopoiesis paper published in Blood Journal!
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Out in @BloodJournal today, @alyssa_c_parker developed an accurate way to monitor clonal dynamics in #CHIP that makes short term changes in clone size a reliable readout for clinical trials. @VUMCgenetics @VUMCDiscoveries 👇
Is DNA sequencing sufficient for monitoring progression of clonal hematopoiesis? We present a novel DNA methylation sequencing assay that captures blood cell composition! 🩸 @BloodJournal @AlexBickMDPhD 🧵1/12
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Sad as yet another randomized, Phase 3 Trial in higher-risk #MDSsm - this one of AZA + Tamibarotene vs AZA alone with RARA+ - fails. We need to power these adequately to show incremental overall survival improvement, and not focus on CR! ☹️🩸😡
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Out in print! Risk prediction for clonal cytopenia: multicenter real-world evidence | Blood | American Society of Hematology | Proud to have contributed to this multicenter collaboration!@SylvesterCancer #CCUS #MDSsm #leusm #hematology
ashpublications.org
Key PointsA 3-parameter CCRS model was devised specifically for patients diagnosed with clonal cytopenia.The CCRS offers precise CCUS risk assessment for p
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Happy to share our article on lenalidomide-associated Acute Lymphoblastic Leukemia. We hope that it may help the physicians to better monitor this risk. https://t.co/UGeReEhozf
nature.com
Blood Cancer Journal - Acute lymphoblastic leukemia in patients treated with lenalidomide for multiple myeloma: a safety meta-analysis of randomized controlled trials combined with a retrospective...
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The Olympic flame today @GustaveRoussy carried by a young cured patient, relayed by two staff members, symbolizing the flame that drives staff, doctors & researchers in the service of patients living with #cancer #1⃣ in Europe 🙏@valdemarne_94
@VilleVillejuif @Paris2024_JO
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How does clonal haematopoiesis evolve to leukaemia (AML)?🩸How long does it take?⏳ ⭐️Excited to share our preprint!⭐️ Using serial blood samples collected BEFORE diagnosis of AML we unveil the somatic evolution📈 that occurs in the decades pre-diagnosis:
biorxiv.org
Somatic evolution in ageing tissues underlies many cancers. However, our quantitive understanding of the rules governing this pre-cancerous evolution remains incomplete. Here we exploit a unique...
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🎓 Félicitations aux cinq lauréats des concours CNRS/Inserm Chaque année, le @CNRS et l’@Inserm organisent des concours très sélectifs pour recruter leurs nouveaux chercheurs titulaires. Cette année, parmi les cinq lauréats pour @GustaveRoussy, quatre mènent déjà des recherches
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What better way 2 begin the academic year than 2 learn the “16+2” molecular subgroups of #MDSsm …. Never a better time to be a #hematopathologist 🎉 Going frm 3 genetically defined groups (multi TP53, SF3B1 and del 5q) of MDS to 16 👇🏼is a major advancement in our understanding
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Out in @NatureAging today, @taralynn_mack & @MichaelR21 identify epigenetic and proteomic signatures associated with #CHIP clonal expansion
nature.com
Nature Aging - Exploring the clonal expansion of somatically mutated hematopoietic stem cells with aging, Mack, Raddatz et al. quantify rates of clonal expansion in 4,370 individuals in the...
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CONGRESS | #ASCO24 Alexandre Bazinet @MDAndersonNews demonstrated that, in unfit patients with ND AML, 7-day courses of HMA-Ven were associated with similar CRc rates, and potentially less myelosuppression and early mortality, vs standard dosing. Prognostic risk signature
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Happy to share our article on Clonal Hematopoiesis in phase I patients. ⚠️Prevalence of 41% No impact on OS, slight PFS benefit with targeted therapies No major toxicity @CapuBaldini
@GustaveRoussy
https://t.co/102opC97HD
ascopubs.org
PURPOSEWith liquid biopsy's widespread adoption in oncology, an increased number of clonal hematopoiesis–associated mutations (CHm) have been identified in patients with solid tumors. However, its...
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