Indicatrix Crystallography
@IndicatrixNCL
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Crystallising the Uncrystallisable
Newcastle, UK
Joined July 2020
How does Encapsulated Nanodroplet Crystallisation work? Watch this video given by Indicatrix CEO Michael Hall at the @ABXNetwork Winter Conference https://t.co/h0Pl8OKzHb
#Crystallisation #drugdiscovery @ChemistryNCL @PlymUni
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Come join us @UniofNewcastle @ChemistryNCL for a postdoctoral position #pdra in #crystallography with @Mike_Pro_1978. Working on high throughput and high pressure crystallisation, and #SCXRD.
jobs.ncl.ac.uk
Research Assistant/Associate in National Crystallography Service
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An epic paper from @Jess_Metherall! High-throughput encapsulated nanodroplet screening for accelerated co-crystal discovery. https://t.co/7S2ZcZf9xp
#crystallography #crystallization #crystals #xrd #drugdiscovery #pharma #pharmaceuticals #drugdevelopment #chemistry
pubs.rsc.org
Co-crystals are composed of two or more chemically inequivalent molecular species, excluding solvents, generally in a stoichiometric ratio. Co-crystals are particularly important in pharmaceutical...
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New! HTP #cocrystals via #ENaCt out now in @ChemicalScience. >50 #SCXRD structures! Amazing work by #PhD @Jess_Metherall with @Mike_Pro_1978
@AstraZeneca @ChemistryNCL High-Throughput Encapsulated Nanodroplet Screening for Accelerated Co-Crystal Discovery
pubs.rsc.org
Co-crystals are composed of two or more chemically inequivalent molecular species, excluding solvents, generally in a stoichiometric ratio. Co-crystals are particularly important in pharmaceutical...
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Well done to 1st year PhD student Giovanna, for being awarded the @IUCr Best Poster award at #BCA25 meeting at Leeds. @Mike_Pro_1978 @ChemistryNCL @SciencesNCL
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ROY reclaims its polymorphic royalty status!—Polymorphism refers to the phenomenon where the same substance can exist in multiple crystalline forms, and this property is crucial in the development of materials and pharmaceuticals. In their recent article in @J_A_C_S, Weatherston,
pubs.acs.org
Polymorphism, when a substance can exist in more than one crystalline form yet return to the same liquid or solution phase, is characterized by differences in packing or molecular conformation....
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@Pance_Naumov @J_A_C_S Awesome to see this out in @J_A_C_S, lots of work by Jake on developing HTP crystallisation methods for polymorph screening #ENaCt. @ChemistryNCL @Mike_Pro_1978, with funding from @IndicatrixNCL
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great to see this work published, well done Jake. It is another win for ENaCt and the excellent collaboration with @DrMichaelJHall
pubs.acs.org
Polymorphism, when a substance can exist in more than one crystalline form yet return to the same liquid or solution phase, is characterized by differences in packing or molecular conformation....
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Great to see this from PhD student Jake and @Mike_Pro_1978 out in @J_A_C_S. Record breaking 14th ROY #polymorph from HTP #crystallography by #ENaCt. @ChemistryNCL Polymorphic ROYalty: The 14th ROY Polymorph Discovered via High-Throughput Crystallization
pubs.acs.org
Polymorphism, when a substance can exist in more than one crystalline form yet return to the same liquid or solution phase, is characterized by differences in packing or molecular conformation....
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Breaking out our records is becoming a common occurrence! Polymorphic ROYalty: The 14th ROY Polymorph Discovered via High-Throughput Crystallization | Journal of the American Chemical Society https://t.co/zUVGmyL4of Congrats Jake Weatherston, @Mike_Pro_1978 and @DrMichaelJHall
pubs.acs.org
Polymorphism, when a substance can exist in more than one crystalline form yet return to the same liquid or solution phase, is characterized by differences in packing or molecular conformation....
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New paper highlighting #ENaCt #crystallography for complex natural products, with work by ICX scientist Dr L Mardiana & @OberliesGroup @Mike_Pro_1978 @DrMichaelJHall @ChemistryNCL Studies on the epipolythiodioxopiperazine alkaloid verticillin D: Scal...
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Just out, a world record for molecular crystal polymorphs via #ENaCt. Preprint with Jake Weatherston @Mike_Pro_1978 @ChemistryNCL @SciencesNCL. Polymorphic ROYalty: The 14th ROY Polymorph Discovered via High-Throughput Crystallization | ChemRxiv -
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ICX Senior Scientist Dr Mardiana putting their crystallisation skills to the test to support work by @palmaniello @PalmaGroup with @drmichaeljhall @ChemistryNCL, on peptide-based Pd2L4X4 cages in this new paper in Chemistry Europe @ChemistryEur
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Happy to share our preprint using HTP robotics (@SPTLabtech) and #ENaCt to explore co-crystal space. Great work Jess! with @Mike_Pro_1978 @ChemistryNCL @ASTRAZENECAUK High-Throughput Encapsulated Nanodroplet Screening for Accelerated Co-Crystal Discovery
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Nice to see our high-throughput organic molecule crystallisation methods (ENaCt) highlighted at the @SPTLabtech stall here at Denver. Real time demo on the mosquito too! @ACAxtal #ACA2024 @ChemistryNCL @IndicatrixNCL
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The crystal structure of methyl shikimate contains 12 crystallographically independent molecules (Zˈ = 12). Nice piece of work, published in @CGD_ACS by @Mike_Pro_1978 and colleagues.
pubs.acs.org
Zˈ is a parameter used to denote the number of symmetry-independent molecules in the asymmetric unit of a crystal structure. High Zˈ (>1) crystal structures are relatively uncommon and are thought to...
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Jessica P. Metherall et al.: High-throughput nanoscale crystallization of dihydropyridine active pharmaceutical ingredients #SingleCrystalXRayDiffraction @studentsncl @studentsncl @studentsncl... #IUCr
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Always nice to have your work cited by the best provider of innovative lab solutions 😍 the High-quality Swissci plates play a huge part in our ENaCt technique allowing '000s of nano-crystallisation experiments to reiably take place. Find out more below: https://t.co/UvPfezR4gk
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Congrats to our Industrial Placement Student Erin, presenting some of her work at the #BCA23 @britcryst. With support from @DrMichaelJHall and @Mike_Pro_1978
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New review out on advanced crystallisation methods for small organic molecules in ChemSocRev, including #ENaCt. Collaboration between the @ChemistryNCL teams of @DrMichaelJHall @Mike_Pro_1978 and @colessj @UK_NCS
pubs.rsc.org
Molecular materials based on small organic molecules often require advanced structural analysis, beyond the capability of spectroscopic techniques, to fully characterise them. In such cases, diffra...
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Brilliant to see this work in print, containing crystallisatio from @IndicatrixNCL and @Mike_Pro_1978, helping to solve stereochem by xray #scxrd #enact with @Tocris Diastereomeric Resolution Yields Highly Potent Inhibitor of SARS-CoV-2 Main Protease
pubs.acs.org
SARS-CoV-2 is the causative agent behind the COVID-19 pandemic. The main protease (Mpro, 3CLpro) of SARS-CoV-2 is a key enzyme that processes polyproteins translated from the viral RNA. Mpro is...
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