Igor Khalin 🇺🇦
@IgorKhalins
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Junior Professor Chair @BbCaen working on blood-brain barrier, brain targeting, stroke, microthrombosis and advanced imaging using nanotechnology
Munich, Bavaria
Joined February 2019
Huge thanks to all co-authors, who made this story possible @aklymchenko @MaSchifferer and supported it @LMU_Muenchen @ISD_Research @Inserm @BbCaen Here is the paper: https://t.co/0jD9X3wg2Q
pubs.acs.org
Nanotechnology holds great promise for improving the delivery of therapeutics to the brain. However, current approaches often operate at the organ or tissue level and are limited by the lack of tools...
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7/7 Finally, microthrombi = not only damage, but accumulator and delivery gateways for nanoscale medicines.
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6/7 Using FRET we showed that microthrombi act as sites of nanoparticles accumulation, extravasation and drug release.
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5/7 Interesting! The longer microthrombus persists, the more caveolae in the endothelial cell surrounding it.
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4/7 We were surprised that BBB leakage was always associated with and followed to microthrombi
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3/7 Then we created a Nanostroke model using minimagnet allowing real-time tracking of such events and found formation of post-stroke microthrombi
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2/7 First we observed that after transient MCA stroke in the lesion area the center of BBB leakage was associated with accumulation of nanoparticles inside vascular occlusions.
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1/7 Absolutely happy to share the final piece of our trilogy exploring the mysterious link between microthrombi and the blood-brain barrier! Microthrombi aren’t just pathological - they can be used. Here the full story 👇
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Precise whole-body biodistribution of nanocarriers—a big step forward in translating nano-scale systems. Thrilled to have collaborated with this fantastic team.
LNP/mRNA therapeutics and AAV-based approaches require cell-level precision to achieve success without significant toxicity to other cells. To enable this, we now introduce SCP-Nano🤗 in @NatureBiotech: an AI-based technology for precision nanotechnology. https://t.co/1YniGZr4O4
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Traditional fMCAO stroke models create variable infarcts involving both MCA&PCA areas, increasing the risk of misinterpretation. Our new PURE fMCAO model guarantees consistent MCA-only infarcts, reducing variability and improving stroke research💪Just out:
journals.sagepub.com
Current techniques for inducing intraluminal filamentous middle cerebral artery occlusion (fMCAo) in mice produce highly variable results and often cause additi...
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Had a fantastic time presenting at #EANS2024 on blood-brain barrier dynamics following traumatic brain injury! Exciting insights into how microthrombi affect BBB integrity. Thanks for the great discussions! #BBB #Microthrombi @ISD_Research @BbCaen @Inserm
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Microglia are not necessary for maintenance of blood-brain barrier properties in health, but PLX5622 alters brain endothelial cholesterol metabolism: Neuron
cell.com
Profaci et al. show that microglia are not required for BBB maintenance in young, healthy adult mice. Surprisingly, PLX5622, a drug widely used for microglial depletion, alters CNS endothelial...
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Truly happy that our work will be presented at #FENS2024 in Vienna. If you are interested in how #microthrombi damage #BBB causing #neuroinflammation please check @AntoniaWehn poster today. @BbCaen @LMU_Muenchen @ISD_Research
Excited for day 4 at #FENS2024 in sunny Vienna! If you want to find out more about microthrombosis and BBB dysfunction following traumatic brain injury, come check out my #Poster PS06-28PM-246 this afternoon.
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To see or not to see🔬 Excited to share our latest review which dissects challenges and propose cutting-edge techniques for tracking #nanoparticles across the #BBB Many thanks to @LMU_Muenchen @BbCaen @Lab_Klymchenko @ISD_Research
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Excited to share a preprint with my first experience supervising a post-doc who achieved groundbreaking results!💥 Sodai’ s exceptional work uncovered the reasons behind huge variations in fMCAo stroke model and led to creation novel PURE-MCA mouse stroke https://t.co/2LHpmypQM0
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It was a pleasure to spend these days @unistra working together with @Lab_Klymchenko diving to fluorescent nanoworld. Thank you @aklymchenko for opportunity to give a talk and looking forward to continue exciting collaboration together. @BbCaen @ISD_Research
The jouney into the brain by advanced imaging with ultrabright fluorescent nanoparticles - great talk by @IgorKhalins, our long-term collaborator from @LMU_Muenchen We are happy to welcome Igor in the lab! @unistra @CNRS_Alsace
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Really enjoyed to contribute to this excellent study from @erturklab It was exciting to follow immune cells in action within the skull in real-time 🧠🔬Thank you @ilginkolabas for fantastic collaboration! Please, check the full story here 👇
Exciting🥳 Our new study in Cell shows that our skull is a gateway for diagnosing & potentially treating brain diseases such as Alzheimer's & stroke. Imagine a future where a portable sensor on the skull can monitor brain health! @CellCellPress
https://t.co/gXZzgOv8Ps 🧵👇🏼with🔈
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I’m thrilled to start as Junior Professor Chair at @BbCaen. Looking forward to diving deeper into blood-brain barrier world using potential of #nanotech. I will keep fostering strong ties with @ISD_Research. Let's shape the future of #neuroscience together. #NewPI #BBB #Research
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Had a stimulating discussion at the @ISD_Research retreat, diving into the role of microthrombosis in stroke and its implications on the blood-brain barrier. More research is needed, but the dialogue was promising. #ISDResearch #StrokeResearch #microthrombosis #bloodbrainbarrier
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📢 Exciting opportunity at our team in @HelmholtzMunich! We're seeking a Staff Scientist with expertise in Mass Spectrometry. Join us in driving cutting-edge research at the intersection of biology, chemistry, engineering, and AI. Learn more here https://t.co/2p15ZuTC5H
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