Guerrero-Cazares lab
@HugoGuerreroLab
Followers
703
Following
436
Media
47
Statuses
167
Neurogenesis and Brain Tumors Lab @MayoClinic. We study interaction of glioblastoma with factors of the SVZ 🧠 . Views expressed are our own.
Jacksonville, FL
Joined December 2020
New paper by @marissarussoo A novel methodology to purify high quality #extracellular_vesicles from #GBM cells and profile their protein content. Collab with @emilynorton295 @DoctorQMd @verobelzil and Tukiet Lam 📘JEV @IsevOrg
isevjournals.onlinelibrary.wiley.com
Glioblastoma (GBM), the most aggressive primary brain tumour in adults, presents significant challenges due to its universal recurrence and limited survival rates. A key driver of GBM progression is...
1
3
10
Putting the brightest inquisitive minds together to find cures for cancer @MayoClinicNeuro
@MayoClinic
@MayoCancerCare
@HopkinsNsurg
@HopkinsEngineer
@JohnsHopkins
@uminn
@UMBaltimore
@KKLabJHU
#washDC
@paosmeade
@HugoGuerreroLab
@Honggangcui
@MayoInvents Inspiring
2
6
62
Down over 60%. That’s how far federal research funding has fallen compared to this time last year. Every delay in funding is a delay in delivering for the health of American people.
154
464
1K
“The impact of the collective executive orders and directives appears devastating.”
science.org
Researchers facing “a lot of uncertainty, fear, and panic”
9
124
199
This weekend, we are featuring Dr. Ian Parney. Listen in as he shares how impactful practicing at a teaching hospital is and the positive impacts it has on providing the best patient care and outcomes. @IanParneyMDPhD #Neurosurgeon #NeuroTwitter #MayoClinic
0
5
20
🥂to another great @NeuroOnc meeting during #SNO2024! We had a great time with new and old friends and planning projects with upcoming stars! See you again for #SNO2025! In #Hawaii @paosmeade @aurafig @garciaCesar_A @steph_jeanneret @countryPandey @eugeniaturino
0
4
22
Thanks @NeuroOnc the opportunity to present our work on GBM Invasion and ECM stiffness!! Very excited to be here and learn from leaders in the field! #SNO2024 @DoctorQMd @DoctorQMDLab @paulaschiappa1 @emilynorton295 @HugoGuerreroLab @tae_hwang @KKLabJHU #NeuroOncology
0
2
23
#MayoClinicFL researchers report new discoveries in one of the most aggressive forms of brain cancer and a rare disease that causes cognitive decline. Learn more: https://t.co/R4e17fIkqm
@MayoClinicNeuro
0
2
8
2 new NIH grants coming at the same time! We are #hiring now. Looking for a new #postdoctoral fellow to join our team. Recent #PhD graduate with skills in #cancer_biology #cell_culture #multiomics and #in_vivo_models
@MayoClinicNeuro More info:
linkedin.com
Today’s top 3,000+ Postdoctoral Research Assistant jobs in United States. Leverage your professional network, and get hired. New Postdoctoral Research Assistant jobs added daily.
0
13
38
Magnificent talk @NINDSdirector @MayoClinicNeuro @MayoClinic a golden age. Extraordinary leader and visionary. So much appreciated Dr Koroshetz @NINDSDiversity @NIH_NINDS @NIH
1
6
45
Tremendous talk today by @NINDSdirector as our The James C. and Sarah K. Kennedy Dean of Research Lecture Speaker. @DoctorQMd @HugoGuerreroLab @emilynorton295 @paosmeade @JEmilianoSG @lmichmd @ManuelaAB99
0
4
12
In patients, the expression of cathepsin B is increased in GBM areas proximal to the lateral ventricle.
0
0
0
Back to in vivo, silencing cathepsin B expression not only improves the survival of animal models but also eliminates the negative impact of proximity to the lateral ventricles.
1
0
0
🔬 We confirmed that cathepsin B can induce senescence in neural progenitor cells in vitro.
1
0
0
🔎 In a second cell-specific proteomic screening, we identified cathepsin B as a protein upregulated in GBM cells upon interaction with neural progenitor cells.
1
0
0
🧬 This led us to investigate senescence markers, where we observed overexpression of p21 and p16 in the SVZ when GBM cells are nearby.
1
0
0
🔬 We then used MetRS L274G to conduct cell-specific proteomics on nestin+ cells in the SVZ and identified SLFN5 as a protein overexpressed when tumor cells are nearby.
1
0
0
📊 First, in immunocompetent models, we observed that proximity to the lateral ventricle negatively impacts survival, mirroring human data. Additionally, SVZ cells show reduced proliferation and become arrested as B cells.
0
0
0
🚨📄On our new publication in @ScienceAdvances, @emilynorton295 uses #Cell_Specific_Proteomics to uncover how cathepsin B drives #GBM malignancy near the #SVZ and induces #Neural_Stem_Cells #senescence This breakthrough offers new insight for #GBM
https://t.co/PgjISUFeYO
3
20
53
Adolfo Rojas-Hidalgo @udechile 🇨🇱 present at #SMBE2024 with a great poster on our @LatinCells @cziscience project! @vin_maracaja @morestrada @CarlosOR_ @JAntonioCorona @Lu_span @HugoGuerreroLab @PatriciaPossik @Pati_Severino @raverdugos
1
5
17