Hello! We are super excited to have this paper out as a preprint: "Flux Sampling in Genome-scale Metabolic Modeling of Microbial Communities" Quick thread: https://t.co/ROMP03v0IN

Look at the distribution of z-values from medical research!

Bioenergetics: Increasing Calories Out “We are currently expending about 220 calories per day less for males and 122 calories per day less for females than people of our age and body composition were in the late 1980s. These changes are sufficient to explain the obesity epidemic

Also “eat less than your body needs to survive in order to survive longer” is of course ridiculous. Calorie restriction below bmr is not good for you

At this point I’m suspicious of all longevity science that’s not done in humans

I think I’m starting to believe Lamarck more than Darwin. And the differences between the two theories has huge implications for how we research cancer biology and treatment..

𝗪𝗵𝗮𝘁 𝘄𝗲 𝘀𝗲𝗲 𝗶𝗻 𝗰𝗮𝗻𝗰𝗲𝗿: - A cell’s inability to oxidize glucose. - A resulting excess of lactate.[19] - Impaired glucose metabolism means reduced ability to regenerate glutathione, leading to oxidative stress.[20] - Low mitochondrial NAD/NADH ratio.[21][22] -

Article published a couple of days ago. Every figure in the article is AI generated and totally incomprehensible. This passed "peer-review" https://t.co/8oeyjbn098

Glad to see this paper published! I hope you all will find it interesting, it was a fun project with @USCSysBio_Lab https://t.co/YXNORhNMYN

More good news! Longer blog post coming soon...but my dear ppl, I think we have a "signal". Ray Peat right again! A combo of vitamin B1/B3/B7 & aspirin CURED 2 out of 3 mice from a lethal HUMAN tumor w/ 100% lethality & no reported spontaneous regression. https://t.co/dMCLBoTfb6

Rice and wheat, two of the most crucial food staples worldwide, have experienced a significant decline in nutritional quality over the past 50 years. The essential mineral concentration in rice has decreased by 36%, while in wheat, it has dropped by 57%. At the same time,

after sharing the news with family and friends, i am thrilled to announce that i have been promoted to Professor of Biomedical Engineering and Quantitative and Computational Biology @USC !! @USCViterbi @uscbme @qcb_usc

NEW Perspective: Kost, Patil, Friedman, Garcia & Ralser argue that metabolic exchanges are ubiquitous in natural microbial communities @kostchristian @kiran_r_patil @JFriedman_micro @sarilog @ralserlab

#throwback to just two weeks ago when we celebrated @USC commencement! lab Ph.D. grad #6 @colincess and #7 @GelbachPatrick, plus the amazing @uscbme student Ariella Simoni! so proud of all their accomplishments! @USCViterbi

The eternal white pill: “The principles of embryology keep functioning throughout life” - Ray Peat

In place of the old belief that “we are defined and limited by our genes,” the new perspective is showing us that we are limited by our environment, and that our environment can be modified.

sad to miss #MathOnc23, but glad that the newly minted Ph.D. @GelbachPatrick is there and has the chance to present his recent work. check out the preprint for the full story!

Thanks for reading!

For the future: the main reason @USCSysBio_Lab and I did this is because we want to study metabolic interactions in the tumor microenvironment (with @MumenthalerLab @ngraham @MathCancer) where the idea of a single cell goal (w FBA) is less supported, and sampling could be better

Altogether, this was meant to be a simple methods-based paper to study how predictions are affected by sampling of genome-scale models of communities vs traditional FBA. Overall pretty fun!