Jeff Bezos famously said, “Your margin is my opportunity.”. Now, your office is your competitor’s opportunity, writes @chris_herd. Any company that’s less remote than its competitors risks losing its most talented people. Why remote startups will win the war for top talent 🧵👇.

Machine learning when paired with biological data has the potential to forever change the way we face diseases including cancer, says @cjimmylin of @Freenome. But there will be challenges along the way as Lin outlines in this Q&A. 👇

Instead of companies stuffing themselves on SaaS, @AndrejSafundzic argues for a new kind of software diet. One that changes the priorities of IT, security, and procurement from fixing problems to helping them create infrastructure that empowers employees.

RT @derrickharris: Did We Overeat on Software? < @AndrejSafundzic of @lumosidentity on how companies can treat SaaS….

RT @balajis: It was easier to found Bitcoin than to reform the Fed. It is easier to start a new city than to reform San Francisco. https://….

Cities have been called "the largest technology we make." 🌃. We should be asking these questions, then, before building them, says @zachcaceres. "Is it expensive to run?"."Does it scale?".And especially: "How good are its APIs?"

37signals (Basecamp/HEY) CEO @jasonfried advocates "short-term thinking" when running a company. No long-term plans. No to-do lists. You make decisions in the moment and the maximum amount of time devoted to any project is 6 weeks. He explains why 👇

In the same way e-commerce has decimated many physical stores, @chris_herd believes virtual companies will crush office-based companies. Read more:

For companies that have gone or are planning to go to a hybrid-remote model, @chris_herd explains why "hybrid" needs to mean the same thing to management and employees, because it often doesn't.

RT @stephsmithio: Do you think immersive reality will ever get good enough that we lose sight of what's "real" and what isn't?.

Far too many products fail because there’s simply no demand for them. How does that happen? By overlooking user research. @Sprig founder @ryanglasgow provides a blueprint for investment in research to fuel the right decisions at every stage of growth.

RT @mignano: SuperGoals not only saved @anchor on multiple occasions, but helped us reach new heights on our path to reinvent podcasting.….

When your startup is on the line, SuperGoals create focus, says @anchor founder @mignano. SuperGoals have an urgent timeframe, an open-ended method of achievement, and a single measure of success.

RT @DrNikkino: Have you heard about synthetic embryos? Wonder what they are, how scientists are using them, and what they WANT to do with t….

New models for synthetic embryos have recently emerged, but bioengineers aren’t growing humans now. The immediate goals, explains @Cambridge & @Caltech scientist @ZernickaGoetz, are to understand how life is created and teach us how to rejuvenate tissues.

RT @laurenmurrow: I interviewed @jasonfried on work culture. This bit, on why writing > brainstorms, stuck:. "You’ve got to be able to full….

RT @jasonfried: New interview re: the power of short-term thinking, figuring it out as you go, flowing with human nature, getting comfortab….

How to break the cycle of technology panics:. Instead of being reactive, science should be proactive. If researchers need 5 years to begin understanding something, the process shouldn’t start while everyone’s hyped up and politicians are demanding answers.

The Sisyphean cycle of technology panics (and how to break it). In his new book, @heyfeifer writes about @OrbenAmy’s four-step theory for what keeps happening when a new technology takes hold, especially with young people.

No long-term planning. No politics. No Zoom. No 10-12 hour days. No project managers. Fully remote. @jasonfried shares his unconventional approach to running agile companies.

Founder & CEO of @Firstbase, @chris_herd, explains why he believes remote startups will win the war for top talent: