L Peruzzotti-Jametti
@Dr_LPJ
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Neurologist and researcher @Cambridge_Uni, working on neuroinflammation and multiple sclerosis
Cambridge, England
Joined April 2010
Finally, it's out!!! Please read, enjoy, and share our latest publication on @Nature! One step closer to understanding progression in #MultipleSclerosis! Thanks to all the collaborators and to the @Pluchinolab .
www.nature.com
Nature - Blocking mitochondrial complex I in pro-inflammatory microglia protects the central nervous system against neurotoxic damage and improves functional outcomes in vivo in an animal disease...
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RT @Pluchinolab: Applications are invited for a highly organised and proactive Project Coordinator to provide dedicated support to the @Plu….
jobrxiv.org
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
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Glad to see our work featuring in the #Lancet #Neurology Round-Up focused on #MultipleSclerosis in 2024: evolving evidence and new hopes! .Fight MS!.
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Single-nucleus RNA sequencing of human periventricular white matter in vascular #dementia.
www.biorxiv.org
Vascular dementia (VaD) refers to a variety of dementias driven by cerebrovascular disease and is the second leading cause of dementia globally. VaD may be caused by ischemic strokes, intracerebral...
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Giancarlo Comi, morto a 76 anni il luminare della neurologia: era uno dei massimi esperti italiani di sclerosi multipla
milano.corriere.it
Il professore onorario dell'università del San Raffaele aveva avuto un malore giovedì scorso mentre stava parlando a un convegno. Il collega Burioni:«Lascia un vuoto che ora appare incolmabile»
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Professor Giancarlo Comi was a visionary leader in multiple sclerosis research, leaving an indelible mark on the field. His legacy lives on through his groundbreaking work and unwavering dedication to those affected by #multiplesclerosis. @aism_nazionale.
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Comprehensive phenotypic assessment of nonsense mutations in #mitochondria ND5 in mice.
www.nature.com
Experimental & Molecular Medicine - Mitochondria, often referred to as cell's powerhouses, are essential for energy production and health. In this study, researchers used recently developed...
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The massed-spaced learning effect in non-neural human cells.
www.nature.com
Nature Communications - When learning is spaced in time, memory is enhanced, but so far this was only observed in neural systems. Here, the authors show that non-neural cells, including kidney...
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RT @Nature: A scientist who successfully treated her own breast cancer by injecting the tumour with lab-grown viruses has sparked discussio….
www.nature.com
Nature - Virologist Beata Halassy says self-treatment worked and was a positive experience — but researchers warn that it is not something others should try.
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Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli.
www.nature.com
Scientific Reports - Mitochondrial complex I inhibition enhances astrocyte responsiveness to pro-inflammatory stimuli
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Transfer of mitochondrial DNA into the nuclear genome during induced DNA breaks.
www.nature.com
Nature Communications - Emerging genome editing tools have been reported to possess threats to genome stability, while their impact on mitochondrial DNA (mtDNA) remains unknown. Here, authors...
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Interaction between subventricular zone #microglia and neural stem cells impacts the neurogenic response in a mouse model of cortical ischemic #stroke.
www.nature.com
Nature Communications - There is a limited endogenous subventricular zone (SVZ)-derived neurogenic response for brain repair. Here, the authors report that cortical stroke-evoked environmental...
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In vivo imaging in mouse spinal cord reveals that microglia prevent degeneration of injured axons.
www.nature.com
Nature Communications - The mechanisms underlying microglia-neuron interactions are incompletely understood. Utilizing in vivo multimodal microscopy and optical clearing technology, here the...
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RT @RubenQC_Lab: Don't miss this opportunity to learn from Luca Peruzzotti @Dr_LPJ at @InstitutoCajal @CSIC! 🧠 🔬.
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RT @InstitutoCajal: El próximo Viernes, 4 de Octubre, a las 12:30h. en la Sala Washington Buño del #InstitutoCajal, seminario del Dr. Luca….
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Tolebrutinib demonstrated a 31% delay in time to onset of confirmed disability progression in non-relapsing secondary progressive multiple sclerosis phase 3 study.
www.sanofi.com
Tolebrutinib demonstrated a 31% delay in time to onset of confirmed disability progression in non-relapsing secondary progressive multiple sclerosis phase 3 study Data presented at ECTRIMS...
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FDA approves Ocrevus Zunovo, which has the same mechanism of action as Ocrevus, but is available as an HCP-administered SC injection rather than intravenous (IV, into a vein) infusion.
www.nationalmssociety.org
The FDA has approved Ocrevus Zunovo, a twice-a-year HCP-administered subcutaneous injectable DMT for the treatment of MS. Learn more about this medication.
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Unexpected Low Rate of Amyloid-β Pathology in Multiple Sclerosis Patients.
onlinelibrary.wiley.com
The life expectancy of people with multiple sclerosis (MS) has increased, yet we have noted that development of a typical Alzheimer disease dementia syndrome is uncommon. We hypothesized that...
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Lysosomes drive the piecemeal removal of mitochondrial inner membrane.
www.nature.com
Nature - We show that cytosolic inner mitochondrial membrane vesicles, devoid of outer mitochondrial membrane or mitochondrial matrix, are formed during resting state and directly herniate into...
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RT @Pluchinolab: Thanks @ManuelFriese for featuring our work in @nature on the evidence that mitochondrial dysregulation in microglia perpe….
www.nature.com
Signal Transduction and Targeted Therapy - Microglial complex I activity: a crucial factor for smoldering inflammation in the central nervous system
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