Doris Kaltenecker
@Dorie00
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Postdoctoral researcher @HelmholtzMunich | Metabolism | Cancer Cachexia | Transcriptional regulation | Tissue clearing l Light-sheet imaging
Joined August 2010
Amazed to share our new study published in @CellCellPress revealing how the liver contributes to weight loss in cancer via disruption of a circadian regulator and secretion of catabolic factors. Big thanks to @FiskerSchmidt, S. Herzig, @BerrielDiaz 🧵👇 https://t.co/2fvK9ExTMO
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🚀 Our new Science paper is out (w/ B DeMeo, D Burkhardt, A Shalek, M Cortes): https://t.co/NSfnCblwHh We show that active learning + transcriptomic perturbations can guide which exps to run next, boosting phenotypic hit rates >13x. AI not just predicting bio, but designing it.🔁
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New preprint 🔥 showing that blocking JAK1/2 with ruxolitinib boosts food intake, preserves fat, and extends survival in lung cancer–associated cachexia. @eze_dantas
https://t.co/n9FER7D3C9
#CancerMetabolism #Cachexia #LungCancer #JAKSTAT
biorxiv.org
Lung cancer is the leading cause of cancer-related death and is frequently accompanied by reduced food intake and cachexia, a debilitating syndrome characterized by weight loss and skeletal muscle...
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#AITHYRA, Vienna's new Biomedical AI institute, is hiring Postdocs! Come work with us. Openings in: 🔹 Generative AI 🔹 Multimodal ML 🔹 Virology 🔹 Enzyme Function Apply by Nov 20: https://t.co/8jNpkhdw1x
#PostDoc #AI #ML #Vienna #ScienceJobs
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#Throwback REVIEW | @BerrielDiaz, @RohmMaria, S Herzig Cancer cachexia: multilevel metabolic dysfunction https://t.co/qBnbYXgauQ
nature.com
Nature Metabolism - In this Review, the authors highlight cancer cachexia as a complex and multifactorial disorder, and discuss the underlying host-driven and tumour-driven metabolic changes,...
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The largest description of cancer #cachexia to date across all tumor types and over time using data from 60,000 people. @EdReznik redefines what we know about human cachexia integrating genetics, lab values, and treatment lines.
medrxiv.org
Cancer cachexia is a wasting syndrome with outsized impact on morbidity and mortality. Neither the etiology of cachexia, nor its consequences on patient physiology and outcomes, are well-understood....
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Cancer Cachexia Awareness Day. Yesterday, September 26, marked the first Cancer Cachexia Awareness Day. Cachexia is a severe, often overlooked syndrome in cancer and chronic disease. As a surgeon, I witness every day how cachexia limits both quality of life and treatment options
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#NatMetabPicks | In @CellCellPress led by @BerrielDiaz (@HelmholtzMunich) In cancer cachexia, disruption of hepatic REV-ERBα is linked to the secretion of hepatokines that promote tissue wasting. https://t.co/nQLNUKcEs6
cell.com
Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.
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Spatial-DMT is now published in @Nature ! For the first time, we can simultaneously map DNA methylation and RNA transcription in tissue context. Great collab with @zhouwanding lab. Big congrats to Chin @Chin72155594 , Hongxiang @HongxiangFu and team!
nature.com
Nature - DNA-methylation and gene-expression profiling of tissue sections at near single-cell resolution can be used to create detailed spatial maps showing how methylation and transcription...
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Real-time visualization of STAT activation in live cells using genetically encoded biosensors 🇨🇭 https://t.co/cLOv7o7nng
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Dear all, we have a PhD position in lung cancer research. Apply here! https://t.co/qnRByKsu3F Please, RT. #PhDposition
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Thrilled to share our new paper in @ScienceMagazine ! We identify septal LYVE1⁺ adipose macrophages (sATMs) as niche signals that control stem cell fate, restrain beiging & shape obesity susceptibility. Team effort with @FGinhoux and collaborators. https://t.co/mVWJ451FPQ
science.org
Tissue macrophages reside in anatomically distinct subtissular niches that shape their identity and function. In white adipose tissue (WAT), we identified three macrophage populations with distinct...
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How are human brain regions connected? Are the connecting axons thicker and more myelinated the longer these connecting fibers are? In our recent paper we find that indeed, they are! Read the thread below ⬇️⬇️⬇️ https://t.co/wvhUPSYJeq
#neuroscience #whitematter #AI
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Hepatocyte-Secreted Proteins Mediate Cancer Cachexia https://t.co/Q4O47th7yN A #ResearchWatch summary of a recent study by Doris Kaltenecker, Søren Fisker Schmidt, Stephan Herzig, Mauricio Berriel Diaz and colleagues
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In the latest issue! Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia
cell.com
Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.
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Now online! Functional liver genomics identifies hepatokines promoting wasting in cancer cachexia
cell.com
Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.
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A REV-ERBα mechanism by which the liver contributes to peripheral tissue wasting in #cancer cachexia, offering perspectives for future therapeutic interventions https://t.co/M3e1NGdRWL?
cell.com
Cancer-induced liver changes promote body wasting through secreted factors, with circadian regulators and hepatokines being important contributors to cancer cachexia.
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Turns out the liver is an even more important contributor to #cachexia #wasting than previously thought. Check out this latest paper from our institute @HelmholtzMunich
Amazed to share our new study published in @CellCellPress revealing how the liver contributes to weight loss in cancer via disruption of a circadian regulator and secretion of catabolic factors. Big thanks to @FiskerSchmidt, S. Herzig, @BerrielDiaz 🧵👇 https://t.co/2fvK9ExTMO
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A great study out in @CellCellPress and glad to be part. It shows that specific liver‑secreted factors LBP, ITIH3 and IGFBP1 drive muscle wasting and systemic metabolic disruption in cancer cachexia, revealing potential therapeutic targets.
Amazed to share our new study published in @CellCellPress revealing how the liver contributes to weight loss in cancer via disruption of a circadian regulator and secretion of catabolic factors. Big thanks to @FiskerSchmidt, S. Herzig, @BerrielDiaz 🧵👇 https://t.co/2fvK9ExTMO
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