ottavia delmonte
@DelmonteOttavia
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#MysterySolved! Mashreghi Kallinich Goetzke &co show @Nature that. children developing hyperinflammation after SARS-CoV-2 encounter (MIS-C) do so because of reactivation of EBV in B cells caused by excessive TGFbeta which impairs anti-EBV T memory cells!
nature.com
Nature - Multisystem inflammatory syndrome following SARS-CoV-2 infection results from increased serum levels of TGFβ, which impairs the reactivation of virus-specific T cells.
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Researchers have characterized immune and molecular features of 157 patients with different types of #RAG #immunodeficiency, which could improve individualized treatments. @NIAIDNews Read more in Science #Immunology: https://t.co/V6ZxcvihEC
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ASCI member Michail S. Lionakis @LionakisLab @NIAIDNews in @jclinicalinvest: BTK drives neutrophil activation for sterilizing antifungal immunity: https://t.co/nYjuydSoXt
#Immunology #InfectiousDisease
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Truly life changing for patients! Congratulations! @NIAIDNews
In this study, interferon-γ was found to play a large role in the pathogenesis of APS-1. Results were confirmed in studies in animals and led to a trial of ruxolitinib in five patients, who had dramatic responses. Read the full study results: https://t.co/tWXykOMI59
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Wonderful work Mana and Vivien! Congratulations! Thank you for including me in this exciting project. @NIAIDNews
OUT NOW!🥳 I am delighted to share my main PhD project done at @casanova_lab, just published @CellCellPress ( https://t.co/GB439T8SZX). For the first time, we describe the FLT3LG deficiency in humans, leading to a profound reduction of the bone marrow cellularity and progenitors.
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A timely call from @SalliePermar and Robert Vinci on the financial pressures causing declines in pediatricians and pediatric scientists, with 30% of pediatric residency spots unfilled in the match this year. @PSDP_AMSPDC
https://t.co/ZJZ9hjNEnm
statnews.com
A nation with too few pediatricians could see health care costs soar.
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Scientists at #NIAID, @INSERM, @RockefellerUniv & @ChildrensPhila identified PCTRA deficiency as a novel genetic cause of T cell lymphopenia at birth. They also found some variants of this gene cause #autoimmunity, hinting at undiscovered immune pathways https://t.co/tHKUEot7My
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Happy to be part of this ambitious collaborative effort!
@Centogene and @casanova_lab at @InstitutImagine are excited to announce a strategic #research #collaboration to accelerate and de-risk #RareDisease drug discovery and clinical development. Learn more https://t.co/wnPNaMDO1a
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Excited to share new @jacionline paper! "Perturbations of the T-cell receptor repertoire in response to SARS-CoV-2 in immunocompetent and immunocompromised individuals." Amazing effort by @DelmonteOttavia, @ldnotar et al. https://t.co/gvbu6zT2PP
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Happy to share my PhD project on human IL-7 deficiency at @ESIDsociety with supervision of @anne_puel and @casanova_lab #ESID2022
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