DeLisa Research Group
@DeLisaGroup
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We are the DLRG. We engineer bacteria to solve problems in biology and medicine. @Cornell University.
Ithaca, NY
Joined December 2013
My PhD work is out in @NatureComms !โจFor the first time, we show that bacteria can glycosylate full-length monoclonal antibodies. A proof of concept and a key step toward making antibody therapies accessible to all.. https://t.co/TfOOutnNtv
#biotech #glycotime #SyntheticBiology
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A wonderful article on PepMLM by @xiaofei_lin in @GENbio! ๐ Really captures how we think about sequence vs. structure and how, via experimental collaboration, we've gotten biologists (like Ray Truant, @DeLisaGroup, and @AguilarVirology) to believe in sequence-based design. ๐
Protein Language Model Hits Undruggable Targets, No Structure Required PepMLM generates binders to challenging #therapeutic targets across cancer and neurological disease using protein sequence and no structure @pranamanam @Penn
#AI #proteins
https://t.co/gCEIc7oJxo
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PepMLM is out in @NatureBiotech! ๐ญWant a short binder for any target? Just input its sequence + desired binder length โ PepMLM unmasks it. Simple? No way? The results speak for themselves. ๐ ๐: https://t.co/RRZwQe82tu ๐ป: https://t.co/8l3nSNEtHo ๐ค: https://t.co/9aSfxzZZTo
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More than 30% of the world's population lacks access to essential medicines. What if we could make medicines when and where they are needed? Enter #cellfree biomanufacturing. With @DeLisaGroup @mattdelisa we show a new approach to portable medicine making. https://t.co/MDSllmwmIh
biorxiv.org
Rapid and decentralized vaccine production is essential to ensure global preparedness against emerging and re-emerging infectious diseases. Cell-free gene expression systems, which can be freeze-dr...
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The test phase of biological design is too slow. How can we accelerate it? We show how cell-free systems can be used to speed up the study of post-translational modifications for RiPPs and glycosylation. @NatureComms
https://t.co/gq6yUyzdOP
nature.com
Nature Communications - Post-translational modifications (PTMs) are important for the stability and function of many therapeutic proteins. Here, the authors develop a high-throughput workflow...
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Antibodies are important therapeutics, but producing them in bacteria has been difficult due to glycosylation. w/ @mattdelisa @BelenSotomayor5 we discovered an enzyme that can glycosylate the native Fc acceptor sequence. Pretty cool. @NatureComms
https://t.co/V87U62C2G6
nature.com
Nature Communications - Glycosylation of human IgG antibodies in bacterial hosts has proven challenging. Here, the authors identify a bacterial enzyme enabling E. coli to glycosylate IgGs at native...
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@MichaelCJewett @LaiXiWang518 @jeffreyjgray @alabiac Thanks to our funding institutions, especially @DARPA and @doddtra!
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@MichaelCJewett @LaiXiWang518 @jeffreyjgray @alabiac Special thanks to all our amazing co-authors: Dr. Connor Donahue, Dr. Sai Pooja, Dr. May Taw, Sophia Hulbert, Erik Bidstrup, Natasha Owitipana, Alexandra Pang, Xu Yang, and Souvik Ghosal!
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Grateful to work alongside the lab teams led by @MichaelCJewett, @LaiXiWang518, @jeffreyjgray , Parastoo Azadi, and @alabiac. This was an amazing team effort!
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After glycan remodeling, the Fc binds FcฮณRIIIa, unlocking therapeutic potential. Our discovery unlocks a powerful tool for engineering glycoproteins in bacteria, and, we hope, lays the groundwork for manufacturing antibody therapeutics via a more robust, inexpensive bioprocess.
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What if bacteria could glycosylate full-length human IgG antibodies at their native site? In our new @NatureComms paper, we discovered an OST enzyme that enables E. coli to do just that for the first time. @BelenSotomayor5 @mattdelisa
https://t.co/OqMBUXeheq
#glycotime #biotech
nature.com
Nature Communications - Glycosylation of human IgG antibodies in bacterial hosts has proven challenging. Here, the authors identify a bacterial enzyme enabling E. coli to glycosylate IgGs at native...
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Congratulations to @BelenSotomayor5 on receiving the Spring ๐๐๐๐ ๐๐ฎ๐ฌ๐ญ๐ข๐ง ๐๐จ๐จ๐๐ฒ ๐๐ซ๐๐๐ฎ๐๐ญ๐ ๐๐๐ฌ๐๐๐ซ๐๐ก ๐๐ฑ๐๐๐ฅ๐ฅ๐๐ง๐๐ ๐๐ฐ๐๐ซ๐, the highest honor awarded to a graduate student by @Cornellโs CBE Department!
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Thrilled to share that Harry Zou has being awarded the NSF GRFP 2025!!! Heโll be working on novel delivery strategies for ubiquibodies, with applications in targeted protein degradation. Huge congratulations Harry!
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Thrilled to share our efforts in showcasing the manufacturing capabilities of cell-free gene expression for biotherapeutics.
How are we going to develop more domestic manufacturing capability that can deliver medicines? #cellfree biotechnology can help. Check out our new manuscript on scalable cell-free protein synthesis w? @akarimlab @DeLisaGroup @aw_rochelle
https://t.co/29EPjBypOK
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How are we going to develop more domestic manufacturing capability that can deliver medicines? #cellfree biotechnology can help. Check out our new manuscript on scalable cell-free protein synthesis w? @akarimlab @DeLisaGroup @aw_rochelle
https://t.co/29EPjBypOK
analyticalsciencejournals.onlinelibrary.wiley.com
The SARS-CoV-2 pandemic highlighted the urgent need for biomanufacturing paradigms that are robust and fast. Here, we demonstrate the rapid process development and scalable cell-free production of...
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Congratulations to the Chatterjee Lab and Tina Ye from our lab on this exciting new publication! We introduce โdeubiquibodiesโ (duAbs) that selectively stabilize proteins. Our study is now available at @NatureComms ! #SyntheticBiology #ProteinEngineering
Our pLM-designed peptides, when attached to E3 ligases (aka uAbs), enable us to programmably degrade disease targets (think CRISPRi, but for proteins). But what if we want to STABILIZE useful proteins? In @NatureComms, we introduce duAbs! ๐ ๐: https://t.co/lOedXFVvNN ๐งฌ:
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Congratulations to @BelenSotomayor5 on her induction into the ๐๐จ๐ฎ๐๐ก๐๐ญ ๐๐ซ๐๐๐ฎ๐๐ญ๐ ๐๐จ๐ง๐จ๐ซ ๐๐จ๐๐ข๐๐ญ๐ฒ at @Yale as one of the @Cornell representatives! Her leadership, scholarship, character, service, and advocacy embody this prestigious honor #STEM #Leadership
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Huge congratulations to Weiyao Wang on successfully passing her B exam today! ๐๐ Check out her work on engineering affinity-matured variants of an anti-polysialic acid monoclonal antibody with superior cytotoxicity-mediating potency #antibody #Science
https://t.co/QKRjsPyFwf
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Congratulations to @BelenSotomayor5 for winning Merckโs Best Oral Presentation Award ๐ฅ and to Deepali for wining Corningโs Best Poster Presentation Award๐ฅ at the CBE Graduate Symposium! Delisa Lab is on fire, keep shining, team! #science
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