Cooper Jamieson
@CooperSJamieson
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Research Scientist @GileadSciences | @Caltech NIH Kirschstein NRSA Fellow with @francesarnold | @uclachem PhD with @yitang_ucla and @houk1000
Bay Area, CA
Joined March 2020
Enantio- & Diastereoenriched #Enzymatic Synthesis of 1,2,3-Polysubstituted Cyclopropanes by @runzemao, Daniel Wackelin, @CooperSJamieson, @torben_rogge, @Shilong_Gao, @Anuvab_tweet, Doris Taylor, @houk1000 @uclachem, @francesarnold @CaltechCCE in @J_A_C_S
https://t.co/cuRdz3pe1V
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Today in @J_A_C_S, we report two engineered P450 enzymes—a "kinetic-resolution" enzyme and a "diastereomer-differentiating" enzyme—differing by only ONE mutation W263M. The power of #directedevolution #biocatalysis never ceases to amaze me!
pubs.acs.org
In nature and synthetic chemistry, stereoselective [2 + 1] cyclopropanation is the most prevalent strategy for the synthesis of chiral cyclopropanes, a class of key pharmacophores in pharmaceuticals...
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Products from Conjugated Polyenes via Tandem Isomerization and Pericyclic Reactions | JACS @phdmasao @yitang_ucla @uclachem @UCLA @houk1000 @CooperSJamieson #Biosynthesis #Polyenes #Isomerization #PericyclicReactions
https://t.co/MSpJwkz2p6
pubs.acs.org
We report biosynthetic pathways that can synthesize and transform conjugated octaenes and nonaenes to complex natural products. The biosynthesis of (−)-PF1018 involves an enzyme PfB that can control...
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Tandem intermolecular [4+2] cycloadditions are catalysed by glycosylated #enzymes for #naturalproductbiosynthesis by J. Liu, J. Lu, C. Zhang, Q. Zhou, @CooperSJamieson, C. Shang, @houk1000 at @uclachem, J. Zhou, and Y. Hu in @NatureChemistry
https://t.co/pMTkceftyR
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Enzymatic cis-Decalin Formation in Natural Product Biosynthesis @J_A_C_S @isciverse #Chemistry #ChemTwitter #chemed #scicomm #news #Technology #Tech #NewsBreak #Trending #research #science #AcademicTwitter
https://t.co/y5WYGCrDAt
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#Enzymatic cis-Decalin Formation in #NaturalProductBiosynthesis by @phdmasao, Dan Tan, Jiayan Lu, @CooperSJamieson, Daiki Kanayama, @JiahaiZhou, @houk1000 and @yitang_ucla at @uclachem in @J_A_C_S
https://t.co/M4UeIRcwV4
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Still thinking about @dmac68 lecture at @lindaunobel. An unforgettable time at #LINO22 meeting all of you young scientists and Nobel laureates.
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Discovery and Characterization of a Terpene Biosynthetic Pathway featuring a Norbornene-forming Diels-Alderase | ChemRxiv https://t.co/HODi5pvS4S Another collaboration with the godfather @houk1000
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Discovery and characterization of a terpene #biosynthetic pathway featuring a norbornene-forming Diels-Alderase by Zuodong Sun, @CooperSJamieson, @phdmasao, @houk1000, and @yitang_ucla @uclachem in @NatureComms
https://t.co/TPuXLxK80j
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A wonderful article about @artblocks_io current exhibition in Marfa of @VillarealStudio’s Cosmic Reef project and @CooperSJamieson’s Placement, which opened this weekend. https://t.co/VAGu9cESq2
bigbendsentinel.com
Artist Leo Villareal, a contemporary American artist well-known for his computer-generated light sculptures that sometimes take the form of monumental public installations, will have 1,024 generative...
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Placement will be exhibited as unique 1/1 silkscreen prints framed in handmade yellow southern pine frames. Accompanying the exhibition I will begin to offer signed 1/1 silkscreen prints to owners of the Placement NFT. Minting of Placement is open:
GM! We're excited to share our next exhibit at the Art Blocks house in Marfa, TX, running from May-September! @VillarealStudio will be exhibiting select pieces from his curated project, Cosmic Reef. @CooperSJamieson will be displaying pieces from his project, Placement
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Honored to say that I will be participating in the 71st Lindau Nobel Laureate Meeting as a Young Scientist.
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Computational Prediction and Experimental Validation of a Bridged Cation Intermediate in Akanthomycin #Biosynthesis by @CooperSJamieson, @phdmasao, @houk1000, and @yitang_ucla at @uclachem in @J_A_C_S
https://t.co/s6ieYkIHN7
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bktr00968c2 "Lamma" inspired by Bad Cache #2 @CooperSJamieson commissioned by billw https://t.co/YgCgmDkMFo
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Thank you all for your support!!!
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Ambimodal Transition States in Diels-Alder Cycloadditions of Tropolone and Tropolonate with N-Methylmaleimide (Houk) @uclachem @AarhusUni @CooperSJamieson
https://t.co/0L9cKQt3Wb
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Biosynthesis of para-Cyclophane-Containing Hirsutellone Family of Fungal Natural Products by @phdmasao, Thomas B. Kakule, Man-Cheng Tang, @CooperSJamieson, Mengting Liu, Yi-Lei Zhao, @houk1000, and @yitang_ucla @uclachem in @J_A_C_S
https://t.co/LievRfX8KI
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A new reactivity paradigm is described in JACS. 🤓 https://t.co/NauuEQ7A7L All endo higher-order cycloadditions lead to many products.
pubs.acs.org
The cycloadditions of cyclopentadiene and cycloheptatriene with tropone are some of the earliest published examples of [6+4] cycloaddition reactions. We report quantum mechanical studies (ωB97X-D and...
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