A new Nature study just mapped >16 million immune cells across 300+ people. The punchline: immune aging follows a predictable, programmable transcriptomic drift. Aging is software. Not entropy. @Molecule_sci @vitadao @BioProtocol 🔗 Paper:

Much of the active learning literature avoids modelling the bias and noise of the underlying experimental system...

This is an AMAZING PAPER!! Shank3 oligomerization governs material properties of the postsynaptic density condensate and synaptic plasticity: Cell

I'm thrilled to share our work from @JswLab ( https://t.co/CMzQznSXPN). We developed LOCL-TL, an optogenetic approach for monitoring localized translation in mammalian cells. LOCL-TL revealed two mechanistically distinct strategies for mitochondrially localized translation.

I'm excited to share our new preprint on LagTag, a method that recovers both past and present chromatin states from the same mammalian cells. https://t.co/GEGQpN0Ff0

Now online: Ångström-resolution imaging of cell-surface glycans. The molecular organization of sugars in the native #glycocalyx has been resolved at 9 Å using bioorthogonal metabolic labeling & #superresolution imaging of DNA barcodes. #Glycotime https://t.co/HmPzI6ghpa

"Here we present the first direct evidence that H3K4me3 is not a cause but a consequence of transcriptional activation, functioning as a downstream epigenetic response"

Thanks TJ @taekjip for giving me the opportunity to work on this, “Mechanistic insights into direct DNA and RNA strand transfer and dynamic protein exchange of SSB and RPA” https://t.co/LMGHFm6nuQ

Wonderful work by @Wu_Honggui , @JiankunZhang21 ,@tanlongzhi and @XieSunney ! Unprecedented resolutions of single-cell 3D genome structure!🔬🧬

Online Now: Regulation of somatic hypermutation by higher-order chromatin structure https://t.co/QdBUNrgCDQ

Introducing Epi-PHR, the first non-disruptive, high-genomic-resolution, image-based epigenetic profiling method. Allelic Epi-PHR generates the first single-cell phased examination of histone mark deposition and 3D genome architecture at an imprinted locus by any technique. 1/8

Latest from the lab:🧬Decoy DNA🧬can extend the lifetime of DNA-based tension probes >24h by outcompeting DNases and preserving signal integrity in live-cell tension imaging - simple, general strategy for robust mechanobiology in DNase-rich environments. https://t.co/k8QmRYAIio

FACT weakens the nucleosomal barrier to transcription and preserves its integrity by forming a hexasome-like intermediate https://t.co/V0cGQ07qjh

Terminal Genome Viewer (tgv), written in Rust https://t.co/IJDBqud8sG

A new paper reveals that m6A is enriched in gamma satellite DNA II RNA transcripts, regulating satellite transcription and chromosome segregation https://t.co/bWoT6dijQj

Stylus originated from a wonderful scientific collaboration discovering serine DNA recombinases with Ami Bhatt, @BintuLacra, and @MCBassik spearheaded by star researchers @mgdurrant @AlisonFanton @JoshTycko A huge thanks also to Cosmas Giallourakis and @eminkow for their

Thank you @ItaiYanai and the everyone for such exceptional workshops! It's valuable in expanding my perspectives and mindsets. These workshops are essential for researchers. I'll more enjoy the epiphanies and mystic encounters in my contradictory data now 🐘☕!

[1/n]📢How is your spatial analysis *transcript*-omic if transcripts are only aggregated to gene counts? Introducing SPLISOSM, our new computational method for learning the isoform landscape and its regulation from spatial transcriptomics data https://t.co/eBwnwA8Twx

Introducing FISHnet, a graph-theory-based method for sensitive and specific identification of chromatin domains from single-cell sequential Oligopaints data. https://t.co/vS7Rhej3k1

Can blocking “jumping genes” treat diseases and aging? Learn more: https://t.co/AmxBYpuS4c @NewsfromScience