WallerLab
@CamWallerLab
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Waller lab, interested in cells, evolution, parasites and symbionts. Based in Biochem at Cambridge (run by students and staff).
Cambridge, UK
Joined July 2022
RT @CamBiochem: We want to hire an Assistant Professor/Associate Professor in the area of Bioenergetics or Microbiology. Apply here by 9th….
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RT @dudin_o: 🍾Our small #Expansion #Microscopy adventure is only starting!. We are happy to announce that @MooreFound will be funding our e….
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RT @SoldatiLabToxo: Mitochondria are the powerhouse of the cell, producing essential energy for life 🏭⚙️. To synthesize the proteins for th….
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The latest paper from our lab is online now at Current Biology! #dinoflagellates #plastids #endosymbiosis.
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Congratulations to all authors on this work. Great addition to the cryptosporidium research field!.
Targeted CRISPR Screens Reveal Genes Essential for Cryptosporidium Survival in the Host Intestine (full thread in the other place!) @_Lucy_Watson .
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RT @SaterialeLab: Targeted CRISPR Screens Reveal Genes Essential for Cryptosporidium Survival in the Host Intestine (full thread in the oth….
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RT @veupathdb: 📢 In one month, @veupathdb is hosting a FREE virtual workshop! Dec 11-13, 2024, 3 hours per day. Short lectures & hands-on e….
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Great meeting for the LMU-Cambridge Strategic Partnership. Exciting new opportunities ahead! 🇬🇧🤝🇩🇪.@RossWaller3 @MeissnerLab @ElenaJmnezRz @Arctas_fr @siegel_lab @CicutaGroup @Susie__McLaren @Dey_Gautam @oscarbranson @rayner_julian
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RT @McfaddenGeoff: @RossWaller3 @CamWallerLab Ross Waller credits Chrissie Hynde from the Pretenders with figuring out Myzozoa long b….
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RT @McfaddenGeoff: @realBenJen tells us about glycans in cell/cell recognition for symbiosis. #CGUE
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RT @veupathdb: Welcome back! VEuPathDB resources are back online today! We will continue to provide bioinformatics services under a new org….
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There is more to be done, the use of a curated but small set of genes is able to explain the current rooting of the eukaryotic tree of life, however the internal groupings require additional genes, different evolutionary models and of course, more extensive sampling.
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How did they do it?.By using a curated set of genes and examining the alignments under sophisticated but tolerant evolutionary models to explain how different genes evolve
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By using a set of mitochondrial genes across several eukaryotic genomes Laura Eme was able to accurately reconstruct a hypothetical LECA, with features resembling the Excavate group
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LECA is the last eukaryotic common ancestor, there are several hypotheses about how it looked and what functions it performed. From comparative genomics alone we can infer the gene content but not necessarily the origin of different ancestral states, unless we use outgroups
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The proverbial tree of life, it brings a robust picture on how organisms are related to one another and how they evolve. If we go back to the very beginning, we will find LUCA, but this is #CGUE and we'll focus in LECA
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Coordinating the functions of three organelles is crucial for their maintenance, thus, Epithemia is an attractive model for endosymbiosis and organellogenesis, packed in a cell that literally has it all!.Follow @Sarah_Frail's amazing research for more about Epithemia.
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Genes are being transferred from the endosymbiont to the host, proteins are being targetted from the host to the endosymbiont.
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The endosymbiont is on its way to become a permanent resident, and as such the relationship with the host is becoming more intimate
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