AI is helping reveal patterns in our DNA. A recent Nature article features our Principal Investigator David Kelley, whose team is building gene expression models — offering insights into health, aging, and disease. Read more: https://t.co/qdn2WoHY4k

This opens up new directions for research and development of potential new treatments for VWM and other diseases characterized by white matter loss. Read the full article to learn more: https://t.co/lJZ9gfH4Mf (5/5)

The team demonstrated that persistent ISR activation leads to dysfunctional oligodendrocyte maturation and reduced cholesterol biosynthesis. These processes are essential for myelin formation and brain health. (4/5)

Their work highlights the therapeutic potential of this molecule class in early onset Vanishing White Matter (VWM) disease. Fosigotifator, an analog of the activator, is in the clinic in Phase 1b in VWM disease. (3/5)

The authors also showed that an activator of the protein synthesis regulator eIF2B could rescue the neonatal lethality in a mouse model with a severe pathogenic variant in eIF2B. (2/5)

New research from our scientists is shaping our understanding of brain diseases. A preclinical study led by Calico discovered a new link between chronic activation of the integrated stress response (ISR) and dysregulated cholesterol synthesis. (1/5)

Our scientists enjoyed exploring the future of biotech at the inaugural #BayAreaBiotechDay at @UCBerkeley. We’re grateful to be part of a community advancing research and interventions that may help people live longer, healthier lives. Thank you @MTI_UCB for hosting!

Lauren Booth is a Principal Scientist in the Sidrauski Lab at Calico, where she studies the integrated stress response (ISR) to better understand how cells function as they age. Lauren shared what inspired her to join Calico. Explore Life at Calico: https://t.co/Xp8BZNDZrh

This #NationalInternDay, we’re celebrating the interns who joined us this summer to explore the science of aging. Here’s a look at their summer so far.

We’re proud to share that @Forbes has named Cynthia Kenyon, our VP of Aging Research, to the 2025 #ForbesOver50 list. Her pioneering work in aging biology continues to shape how we understand healthspan and age-related disease. Congratulations, Cynthia!

Join us in welcoming our 2025 Summer Interns! They'll spend 12 weeks with our research and technology teams, gaining hands-on experience contributing to projects that explore the biology of aging. We’re glad to have them on board and look forward to what they’ll discover.

@Oliver__Hahn Our scientists are interested in learning more about microglia to better understand how aging affects regions of the brain differently, and translate these insights into potential treatments for age-related neurological conditions. (3/3) #BrainHealthAwarenessMonth #AgingScience

@Oliver__Hahn The blue areas highlight microglia, which are immune cells that help keep the brain healthy. The pink areas show myelinated axons, the insulated fibers that carry signals between brain cells. (2/3)

Why are some brain cells more sensitive to aging? This light sheet microscopy video from Claire Gizowski in the @Oliver__Hahn Lab shows a cross section of a mouse brain after a process called tissue clearing, which makes it transparent so scientists can look deep inside. (1/3)

Aging doesn’t look the same for everyone. With data collected by UK Biobank, we’re studying how genetics shape traits as we age, using large, diverse populations to bridge foundational research and human biology. Read the story: https://t.co/GWqpHuczRq

Leanne Chan, a Principal Assoc. Scientist on our Proteomics team, develops new techniques to help characterize how protein levels change over time and designs automated protein analysis workflows. We asked why she joined Calico. Explore Life at Calico: https://t.co/Xp8BZNDZrh

Aging is the dominant risk factor for the world’s most common diseases, yet the biological processes behind it remain only partly understood. At Calico, we focus on exploring those processes with the goal of improving health as people age. #OlderAmericansMonth

What can aging biology teach us about cancer? Our Head of Oncology, David Stokoe, Ph.D., shares how we study cancer through the lens of aging — using a systems-level approach to uncover mechanisms that could inform future interventions. #NationalCancerResearchMonth

Unlike traditional methods that require specialized tools, Nellie simplifies and standardizes the process, making it easier for scientists to study how cells function as they age. (3/3) Learn more about Nellie in this Calico Story: https://t.co/dzVOmXPLEV #AgingResearch

To help researchers learn more from their cell images, our team developed Nellie, a freely available image analysis pipeline that automates the segmentation, tracking, and analysis of organelles across a wide variety of cell types and imaging conditions. (2/3)