Absolutely delighted to have our work on complex I mutations and hyper antibiotic tolerance through persistence published in @NatureComms: https://t.co/SvfMsWEqzP. A thread: 1/n

I backed snapmaker's u1 3d printer on kickstarter. Cheap 4-head printer for less waste en faster multicolor or multimateral printing from an established company. Seems the sector is finally coming of age. Interested? Have a look yourself

I backed snapmaker's u1 3d printer on kickstarter. Cheap 4-head printer for less waste en faster multicolor or multimateral printing from an established company. Seems the sector is finally coming of age. Interested? Have a look yourself

‘Vlaams Instituut voor Biotechnologie draagt voor 1 miljard euro bij aan economie’

Our colleages @CMN_VIB are looking for a new member: Postdoctoral Researcher - VIB

Big promises to fulfill but happy to see that we got support for our idea of a fast urine diagnostic tool! I will be watching on the side line but have all confidence in the collaborative team that will carry out this development! https://t.co/Nd21zJUzjg

The data was generated by 5 different people @AgtenLieze @SangDNguyen2022, Nele Geerts, @MollLauren40018 and Laure Verstraete. It was fun to put this together with @PhilipRuelens! Big thanks to everyone else involved and of course to my funding @FWOVlaanderen

This likely is one of my final works @Janmichiels0 lab and largely was a collaborative effort between his @KU_Leuven team within @VIB_microbes and the team of @Paulcos3 @UAntwerpen.

What does this all mean? MIC levels clearly are bad at predicting another important aspect of how bacteria deal with antibiotic treatments. Depending on the relevance of heterotolerance in the clinic, only assessing MIC values (current practice) could fail to inform clinicians.

In addition to the high amount of noise, there are also very significant outliers: i.e. strains that show no resistance but are highly antibiotic tolerant or strains with significant resistance but highly sensitive towards antibiotic-induced killing.

Put differently, while a higher MIC value (resistance) generally means the strain will also display higher survival, this is far from a 1-1 relationship. The relationship is so weak that variation in MIC values only explain 11.4% of the variation in heterotolerance levels.

It turns out that, while there is some positive correlation which one could expect, this correlation is very weak and highly dependent on the antibiotic x species.

Assessing the survival has been a tremendous body of work and while we are working on other aspects that dive more into the evolution and molecular mechanisms, we already asked ourself the simple question: How does resistance levels compare to heterotolerance levels?

We assessed heterotolerance and resistance for 2 relevant antibiotics, for 3 major pathogens (E. coli, S. aeruginosa, S. pneumoniae), for a diverse set of strains. In total, we looked at >1000 isolates that come from everywhere in world, across pathologies and throughout history)

Happy to see this work out and about! To our knowledge the largest and most diverse screen of heterotolerance in bacteria together with a comparison to the clinically scored MIC levels that show the resistance of the strains.

I went to the Senate floor to lay out for my colleagues the stunning story of brazen, open corruption during the first 6 weeks of the Trump presidency. I think it's a story everyone needs to know. 1/ So a🧵with the highlights from the speech.

🚨 BREAKING: Russian President Vladimir Putin has reportedly launched a ballistic missile strike on a hotel filled with innocent civilians in Kryvyi Rih, Ukraine. This devastating attack comes just hours after Trump halted the sharing of intelligence with Ukraine—intel that may

Trump's allies are asked a simple question: "What else could a Russian asset actually possibly do that Trump hasn't yet done?"

We are looking for a postdoc to strengthen our team! Interested in large-scale microscopy screens across bacterial species? Please apply via: https://t.co/HGjPtBkrqF... #Microbiology #ERC Feel free to share/repost.

OK PubMed is down It's run by the NIH and the main way to search for academic papers. If this isn't a temporary thing , and is a Trump/Musk doing, academics around the world are royally screwed right now.

RETWEET if you stand with President Zelensky!