Circulating proteins in the blood contain *information* about the age of our organs. https://t.co/wN8pKAJYWe

Online Now! Reversing lysosomal dysfunction restores youthful state in aged hematopoietic stem cells https://t.co/tb95lIyR3G #stemcells

Pressure to publish jumps. And researchers have no time to do science. (New survey from Elsevier) Survey of 3200 researchers: 1. Only 45% of scientists have sufficient time for actual research. 2. For 68%, the pressure to publish today is greater than 2-3 years ago. 3. 29% of

🧠 65-Hour Live Imaging: Hippocampal Neurons Building Circuits Real-time dendritic growth & synaptic remodeling in the rat hippocampus; important to memory & plasticity. 🔬 Continuous multi-day view of neural adaptation. Credit: Louis Romet & Dr. C. Leterrier

Neurons transmit signals through synaptic vesicle release, but the nanoscale dynamics of this process have been unclear. In a new Science study, researchers report using time-resolved cryo–electron tomography to visualize synaptic vesicle dynamics in situ and propose a unified

Our RAEFISH spatial transcriptomics technology is now published in Cell @CellCellPress! RAEFISH enables sequencing-free whole genome spatial transcriptomics at single molecule resolution. This work represents the first time that transcripts from more than 23,000 genes were

We reassessed the @TheLancet 14 dementia risk factors and added poverty, wealth shocks, income inequality, & HIV. This provides a larger estimation of preventable dementia & exposes gender inequities with larger burdens in women. Out in @eBioMedicine https://t.co/jvS2eFsN89.

Klein and Overholtzer @mskcancercenter discuss new findings from the Deretic group (@duque_thabata et al. https://t.co/73IWLjouYg) showing ATG16L, a regulator of lysosomal stress responses, has a day job regulating the v-ATPase. https://t.co/oXPskfkGUJ

A rare genetic variant confers resistance to neurodegeneration across multiple neurological disorders by augmenting selective autophagy: Neuron

The adaptive aging brain… 🧠 https://t.co/AfKTI2DvNu

The fate of mitochondrial respiratory complexes in aging: Trends in Cell Biology

Apoptotic vesicle release from a cell as it gives up the ghost under oxidative stress, as seen by MOSAIC lattice light sheet mode.

In a Science study last year in mice, researchers introduced CHARM, a compact and versatile epigenetic editor that can be used to silence prion protein throughout the brain. Learn more in this #SciencePerspective: https://t.co/b80Gcjzkiw

same data

I’m excited, relieved, and honored to announce that my paper describing non-canonical mitotic mechanisms in the early mouse embryo is out in @ScienceMagazine ! (link at end of 🧵)

Big News: Thrilled to share that my latest PhD work is now published in @Nature. We identify PLA2G15 as the lysosomal BMP hydrolase and show that blocking it improves outcomes in a severe neurodegenerative disease model. Read the article here https://t.co/dFZwLelCac (1/7)

Why do some neurons say “sleep” while others shout “stay awake!” — inside the same brain? In fruit flies, researchers just mapped the molecular chaos behind this nightly tug-of-war. And it’s wilder than we thought. https://t.co/aAYK9TcCNi

The retina is arguably the most impressive part of the brain - it's also the only part of the brain that faces the world directly - it’s a sensor and processor in one Consumes 50% more energy per gram than the rest of the brain. 1000:1 compression from retina to optic nerve

Why do living organisms need sleep? A new theory suggests that myelin acts as a proton capacitor, accumulating energy during sleep. 🧵1/12

STING mediates lysosomal quality control and recovery through its proton channel function and TFEB activation in lysosomal storage disorders https://t.co/Upr5ZVe1Ny