
arpit gupta
@ArpitG_26
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One day molecules will start responding
Caltech
Joined February 2022
Thrilled to share first paper from my postdoc. A structural-guided functional insight into this unique chaperone. Congratulations to co-authors @alfredlentzsch, Alex and @yifan_ucsf lab.
www.science.org
Skd3 efficiently refolds misfolded proteins by assembling both hexameric rings and dodecameric cages.
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RT @pdfiisermohali: Congratulations to Dr. Amar Deep @iamamardeeep on joining IISER Mohali @IiserMohali as a new faculty member in the Depa….
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RT @davidrliu: Another medical milestone! The first patient treated with a prime edited therapeutic shows positive clinical outcomes consis….
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RT @VKohler_Lab: What is #AcademicKindness and why does it matter to me?. #KohlerProteostasisLab #Mentorship #Lead….
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RT @Caltech: Four members of the Caltech faculty are elected to the National Academy of Sciences (NAS) this year. Election to the academy i….
www.caltech.edu
Election to the academy is considered amongst the highest professional honors for scientists.
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RT @ShorterLab: An Msp1-Protease Chimera Captures Transient AAA+ Interactions and Unveils Ost4 Mislocalization Errors .
www.biorxiv.org
Membrane protein homeostasis (proteostasis) is essential for maintaining the integrity of eukaryotic organelles. Msp1 is a membrane anchored AAA+ (ATPase Associated with cellular Activities) protein...
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RT @alfredlentzsch: Please check out this review we wrote in @JMolBiol , together with Profs. Jae Ho Lee and Shu-ou Shan, on the mechanisms….
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RT @iamamardeeep: Our recent work on bacterial Wadjet system is out today in @MolecularCell 🎊🎉.
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RT @AlzResearchUK: Every 3 minutes dementia steals a happily ever after. You can change the ending. Stand with Alzheimer’s Research UK #F….
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RT @DeuerlingLab: We are delighted to have been a part of this Story and want to thank our collaborators Shu-ou Shan at @Caltech and @The_B….
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RT @ShorterLab: The Ability of DNAJB6b to Suppress Amyloid Formation Depends on the Chaperone Aggregation State | ACS Chemical Neuroscience….
pubs.acs.org
For many chaperones, a propensity to self-assemble correlates with function. The highly efficient amyloid suppressing chaperone DNAJB6b has been reported to oligomerize. A key question is whether the...
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Distinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress: Cell Reports
www.cell.com
Bertgen et al. identify the mitochondria-encoded polyN protein Var1 as a nucleation factor for intramitochondrial protein aggregates. Var1 bodies form during acute stress to sequester misfolded...
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RT @ShorterLab: Cryo-EM structures of amyloid-β and tau filaments in Down syndrome:
www.nature.com
Nature Structural & Molecular Biology - Here, using cryo-EM, authors reveal that amyloid-β and tau are identical in Alzheimer disease and Down syndrome. This has implications for assessing...
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RT @aliceyting: LYTACs pioneered by @CarolynBertozzi opened the door to degradation of cell surface and extracellular proteins through lyso….
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RT @DMSabatini: Many, many congratulations to Grace Liu on the publication of her creative thesis work on an evolutionary mechanism for how….
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RT @JackrelLab: 📢We are excited to share that our paper on HTRA1 remodeling of alpha-synuclein is available now online with @NatureComms! C….
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RT @PPMC_UAB: Structure of Amyloid Peptide Ribbons Characterized by Electron Microscopy, Atomic Force Microscopy, and Solid-State Nuclear M….
pubs.acs.org
Polypeptides often self-assemble to form amyloid fibrils, which contain cross-β structural motifs and are typically 5–15 nm in width and micrometers in length. In many cases, short segments of longer...
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RT @davidrliu: If you ever wondered what would happen if one person received 217 COVID vaccine injections over 2.5 years, now you don’t hav….
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RT @amit_tuli: Excited to share latest study from the lab led by a dedicated & amazing graduate student @Kshitizwalia that shows how #ORF3a….
www.nature.com
Nature Communications - SARS-CoV-2 uses the host endolysosomal system for replication and egress. Here the authors show that SARS-CoV-2 virulence factor ORF3a localizes to the late endocytic...
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