Angela Johns
@AngyJohns
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PhD student at @TheVilchezLab @CECAD_ via @CGA_age | #Ageing, #Neurodegeneration, #ALS, and everything beyond and in between | 🇵🇭🇫🇮🇸🇪🇩🇪
Cologne, Germany
Joined July 2021
Check out our new publication on protein quality control, from my masters internship in University of Gothenburg! Thanks for the awesome supervision @ArthurFischbach and Thomas Nyström! Congratulations! 🎉🎉🎉
Very excited to share my latest work on #aging and #proteostasis published now in @NatureComms. Here, we report on engineered, artificial systems to export endogenous or mutant huntingtin protein aggregates from cells https://t.co/Xomv2zdDQI
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PhD Opportunity - I am recruiting a student to investigate mechanisms of co-transcriptional RNA processing in human mitochondria. This is in collaboration with @hauke_hillen and is funded by the DFG @dfg_public . Deadline 3 January 2025. Apply below⬇️: https://t.co/RjEiEglqki
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New paper from the lab! ALS-FUS mutations cause abnormal PARylation and histone H1.2 interaction, leading to pathological changes: https://t.co/eYWcNqmGXz
#ALS
cell.com
Alirzayeva et al. find that ALS-related mutant FUS gains interaction with PARP1 and histone H1.2. Reducing either PARP1 activity or H1.2 levels prevents pathological changes in human motor neurons...
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🎉 Congratulations to @AleXTrifunovic on her @EMBO membership🎉 👩🔬🧬The award recognizes her outstanding research, in particular her pioneering work on the role of mitochondria in aging and disease @CECAD_ 🔬 Read more👇 https://t.co/ZJZIE9bosn
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🎉 Let's celebrate Dr. Saygin Bilican! Saygin, #CGA student of the class of 2019 from @TheVilchezLab @CECAD_ , triumphantly defended his PhD today 👨🎓 We're so happy for you, well done! 🎆
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Hello mitoverse ✨ @mustloveDNA is hiring! If you’re looking for a PhD position in Marburg, DE and you’d like to investigate mitochondrial gene expression, apply here https://t.co/CRI0iCnz8T…. I promise mt gene expression can be fun and Ben is a great mentor. Deadline 05/05/2024
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PhD opportunity! My new research group at the University of Marburg @Uni_MR is once again recruiting a highly-motivated PhD student to investigate molecular mechanisms of mitochondrial gene expression. Deadline 5/5/2024. Apply now using the link below!⬇️ https://t.co/OkU5Wv5ZEG
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✨🚺Happy International #WomensDay ! ✨ Today, on #March8, we honor the diverse voices, experiences, and contributions of women worldwide, as we strive for equality! Here's to all the incredible people who identify as women in our @CECAD_ community and worldwide! #IWD2024
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Adaptive #autophagy regulation revealed 🚨: The molecular starting point for autophagy involves a complex interplay of proteins. Here, @Ansa_Lina @GraefLab demonstrate that the complex composition adapts to specific nutrient deficiencies. More in 🧵 https://t.co/aqkRA0fk1F
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PhD opportunity! My new research group at the University of Marburg @Uni_MR is looking for a highly-motivated PhD student to investigate molecular mechanisms of mitochondrial gene expression. Apply now using the link below!⬇️ Deadline is 3 March 2024. https://t.co/5JSKamqUd6
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Very excited to share our latest work on non-canonical autophagy and aging @NatureAging - thanks to all of the co-authors @Buck, @sbpdiscovery and @RutgersU! Big cudos especially to Assistant Professor Dr. Caroline Kumsta @Kumsta!
Online now! Yang et al. show that inhibition of early-acting autophagy genes in neurons extend C. elegans lifespan, improve proteostasis, and increase #exopher formation via the autonomous WD40 domain-related function of ATG-16.2. @kumsta @thehansenlab
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New year, new beginnings - I am pleased to announce that I am starting as a Junior Group Leader at the University of Marburg @Uni_MR investigating molecular mechanisms of mitochondrial gene expression. Looking forward to working with an incredibly vibrant RNA community!
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We are happy to share our preprint confirming the remodeling of ubiquitination during aging in C. elegans. Check it out!
Very happy to share our preprint that further confirms changes in ubiquitination during aging in C. elegans https://t.co/fozg86YkRB
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Very happy to share our preprint that further confirms changes in ubiquitination during aging in C. elegans https://t.co/fozg86YkRB
biorxiv.org
In previous work, we investigated ubiquitination changes during aging in C. elegans . We identified 2,163 peptides undergoing age-related ubiquitination changes in wild-type animals, corresponding to...
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Wow! Very happy to see that the extensive change in the protein ubiquitination landscape is a major proteostasis signature during aging which is evolutionary conserved in vertebrates
6/Our work demonstrates that remodeling of protein ubiquitylation is a major proteostasis signature of aging extending previous findings in nematodes by @TheVilchezLab to the vertebrate brain
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Terrific work from Alessandro's lab (as usual) demonstrating extensive remodeling of the ubiquitination landscape during aging in mice and killifish! The authors also provide mechanistic insights on how a third of these changes occur
In our latest pre-print, we studied how protein post-translational modifications (PTMs) change during brain aging. Kudos to the incredible team at @AOri_lab @AntonioMarinoMB @DomenicoFraia @panfilovadi @AmitKusahu1598
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Thank you @impetusgrants for your support! @MarkusWehrmann_ had the exciting idea to use his expertise on directed evolution for aging research
Decline in proteostasis and lysosomal function during aging leads to improper protein degradation and accumulation of toxic proteins. @TheVilchezLab @MarkusWehrmann_ are using directed evolution to engineer protein variants that can effectively reduce aggregates during aging.
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Decline in proteostasis and lysosomal function during aging leads to improper protein degradation and accumulation of toxic proteins. @TheVilchezLab @MarkusWehrmann_ are using directed evolution to engineer protein variants that can effectively reduce aggregates during aging.
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It feels unreal to receive my first grant this early on in my career by @impetusgrants. Especially grateful to @TheVilchezLab that enabled and supported me to follow my own ideas and projects. https://t.co/vy76pSWU7j
Decline in proteostasis and lysosomal function during aging leads to improper protein degradation and accumulation of toxic proteins. @TheVilchezLab @MarkusWehrmann_ are using directed evolution to engineer protein variants that can effectively reduce aggregates during aging.
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