Andrew Wood
@AndrewWoodLab
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Research group at the University of Edinburgh using genome editing and targeted protein degradation to study genetic disease and therapy
The University of Edinburgh
Joined December 2013
Preprint alert: pleased and relieved to finally share this work using CRISPR saturating mutagenesis to quantify signalling phenotypes from all possible missense changes in the CTNNB1 exon 3 degron.
Mutational scanning reveals oncogenic CTNNB1 mutations have diverse effects on signalling and clinical traits #bioRxiv.
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We characterise two underlying mechanisms with opposing effects on protein stability and explain their tissue-specificity, providing a rational basis for improved experimental design. Congrats to 1st author Gillian Taylor and all who contributed. Feedback welcome!.
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By surveying a series of CRISPR-engineered mice, we found that tags often change protein expression in some tissues but have little effect, or even opposite effects, in others. Why?.
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Genetic tagging is a cornerstone of modern molecular biology, but it’s no secret that tag fusion often causes unwanted changes in protein expression and function. Understanding how this happens could help us to design more refined and effective models for preclinical research.
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Happy to share our latest work and first manuscript from the Degron Tagging Cluster @MRCMouseNetwork. If you work with protein tags, particularly in tissue biology models, this should be of interest.
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RT @boulter_lab: 🚨We are recruiting🚨. We have a @UKRI_News funded position available @mrc_hgu for a Research Assistant working on Polycysti….
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RT @Green_Ahn: Excited to share my PhD work, out now in @ScienceMagazine ! What governs successful lysosomal degradation of membrane protei….
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RT @alessiociulli: Thrilled to share that, together with my colleagues @UoDCeTPD and collaborators @Boehringer, we report @ScienceMagazine….
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RT @jeffnivala: Published today in @Nature, we describe an approach for single-molecule protein reading on @nanopore arrays. By utilizing C….
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RT @jflier: What if I told you that I co-founded a startup in 1987 that obtained world-wide rights to GLP1 as a metabolic Rx, collaborated….
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RT @DrPipDunne: 🚨RTs please🚨. Apply to join our spatial hackathon, full details below and the call is looking for applicants across a range….
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RT @t_rayon: 1st #prerpint from the lab together with @briscoejames!. Collaborative effort led by @SNakanoh & Desp….
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This is wonderful news. It has been a pleasure to work with Sara through the @MRCMouseNetwork. Congratulations!.
Congratulations to our Director, Sara Wells, who has received an MBE in the King's Birthday Honours List 2024 for services to medical research!.
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RT @MRCHarwell: Congratulations to our Director, Sara Wells, who has received an MBE in the King's Birthday Honours List 2024 for services….
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RT @GenSocUK: Celebrate emerging talent! . Nominate an exceptional young investigator for the Balfour Lecture Award and recognize their rem….
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RT @prakramacha: Thrilled to see @boulter_lab receive EASL emerging leader award. Thoroughly well deserved. @EASLnews @EASLedu @mrc_hgu @E….
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It was a pleasure to be @UniofOxford for the DPhil viva of (twitterless) Ava Van Ess @VdangioE3lab. Many thanks to Ava and @ERADLab for the fun discussion and excellent hospitality #dressdownmondays
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Seeing former mentees lives flourish might just be the best part of our job. Congrats @_Lewis_M_ and @michaela_raab and thanks for letting me and @boulter_lab share your special day ❤️❤️❤️.
Thrilled to be with @AndrewWoodLab at the @mrc_hgu @EdinUni_IGC wedding of the decade!!!!.Between @_Lewis_M_ and @michaela_raab. We don’t just supervise PhDs!!
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Returning from 3 days of inspiring interdisciplinary science at #TPDFocus @UoDCeTPD. Congratulations to the organisers.
The last session of #TPDFocus has come to an end! 🌟 Chaired by Valentina Spiteri, we had great talks from #IngridWertz, @danetteldaniels, #AngelaCacace, @EndriuT, @VesnaVetma, and wrapping up with #RebeccaStevens.
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RT @BinGu31824822: Excited to share: ‘Brd4::Nutm1 fusion gene initiates NUT carcinoma in vivo’. Discover how a chr….
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