Andrew Waters
@AndrewMWaters
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Assistant Professor at University of Cincinnati | Surgical Oncology | Cancer Biology https://t.co/aLk5h86bLS views are my own
Cincinnati, OH
Joined January 2015
Excited to share my first last-author research paper in @CR_AACR where we comprehensively identify and validate resistance mechanisms to KRAS inhibitors in #PancreaticCancer. This work was led by a fantastic medical resident @SzuAunLongMD, and two phenomenal grad students Haley
aacrjournals.org
Abstract. KRAS inhibitors (KRASi) targeting various KRAS mutations have entered clinical trials for pancreatic cancer. Despite promising preliminary clinical responses, most patients relapse due to...
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Identification and characterization of binders to a cryptic and functional pocket in KRAS | Nature Communications
nature.com
Nature Communications - In this work, Beyer and colleagues have utilized display screening technologies to comprehensively chart RAS proteins “druggability” and in doing so unravel a...
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CRISPR-Cas9 Screening Identifies Resistance Mechanisms to KRAS Inhibition in Pancreatic Cancer | Cancer Research | American Association for Cancer Research
aacrjournals.org
Abstract. KRAS inhibitors (KRASi) targeting various KRAS mutations have entered clinical trials for pancreatic cancer. Despite promising preliminary clinical responses, most patients relapse due to...
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November is Pancreatic Cancer Awareness Month. Cancer Center member Nina Steele, PhD, is building a single-cell and spatial atlas of the pancreas and studying tumor microenvironments in therapy. RAS inhibitors are now in trials. Learn more: https://t.co/WkGO8gUUvQ
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Two papers in @CR_AACR highlighting the unique biology of KRASG12R allele in #PancreaticCancer: (A) weaker MAPK activation leading to greater MAPKi sensitivity https://t.co/dBn3WaTdLt (B) PTEN oxidation dependent (and KRAS independent) PI3K activation https://t.co/r6BjIoHgJQ
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Get vaxxed!
🤯 New in @Nature from @MDAndersonNews colleagues @adam_grippin @StevenLin_MDPhD SARS-CoV-2 mRNA vaccines sensitize tumors to immune checkpoint blockade https://t.co/kiZCCnf5Uw
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New paper from @cjder23 @derlabunc in @scisignal Defining the MYC-regulated transcriptome and kinome that support KRAS- and ERK-dependent growth of pancreatic cancer https://t.co/zOfK0rsyRP "almost one-third of ERK-regulated genes were also regulated by MYC in PDAC cells"
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Happy to have had a (small) part in this awesome project that will hopefully "MYC" a big difference in pancreatic cancer research! @cjder23 @bryant_kl @scisignal
This week, a team constructs a wide-ranging molecular atlas of MYC in #PancreaticCancer cells, shows that MYC is needed for many of the oncogenic effects of mutant KRAS, and identifies several targetable MYC-interacting kinases. @cjder23 @UNC_CBP
https://t.co/bsRh0vKpR8
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Moving the needle!
Revolution Medicines Daraxonrasib data in first line metastatic #PancreaticCancer - monotherapy & combination with Gemcitabine nab-paclitaxel. Even monotherapy ORRs and DCRs are impressive! Do you need the chemo? Grade 3 AEs go from 35% to 58%. RASOLUTE 303 will answer.
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We are recruiting! We are building something outstanding at @uofcincycancer. Come join our Department @UCincyMedicine! @SyedAAhmad5 @dgerber6
https://t.co/du8qH9Ok1d
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NCI payline: 4% Likelihood of alien invasion in November: 7% The likelihood of getting a NCI R01 grant is lower than that of an alien invasion during the month of November. Let that sink in. @SyedAAhmad5 #CancerResearch
Still better than the NCI payline!
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First surgery research resident @SzuAunLongMD was super successful. Hopefully I can scrub in with my new scrub cap to watch her and @SyedAAhmad5 or @GregWilson152 perform a Whipple after she goes back into the OR @cincysurgery @dgerber6 @JMU
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I am excited to be speaking at the 7th RAS-Targeted Drug Development Summit, September 16-18, in Boston! I am also co-leading a debate discussing pan-RAS and pan-KRAS inhibitors! Come check it out and hear about the latest in drugging KRAS. https://t.co/H7rssyKpzN
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Long overdue, but super excited to have @NinaSteele17 come to @CincyMedicine to continue her lab and track record of success. Pancreatic cancer, your days are numbered. @SyedAAhmad5 @LuisLaraMD1 @uofcincycancer @krushnacpatra @GregWilson152
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2 points from this https://t.co/PKsSnkhwxJ website regarding $8M in transgender mice titled "YES, BIDEN SPENT MILLIONS ON TRANSGENDER ANIMAL EXPERIMENTS" @realDonaldTrump @elonmusk @DOGE 1. 0 of these studies were making transgender mice 2. The $2.5M study was submitted,
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