Andrew Bortvin
@AndrewBortvin
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Population Genetics | Harpsichord | PhD candidate @HopkinsCMDB
Joined August 2020
Our work in collaboration with the Armanios lab shows that long telomeres (caused by mutations in POT1) extend the lifespan of cell lineages within the blood. This results in higher counts of somatic mutations and higher risk of CHIP and various cancers.
nejm.org
Telomere shortening is a well-characterized cellular aging mechanism, and short telomere syndromes cause age-related disease. However, whether long telomere length is advantageous is poorly underst...
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