Loew Group
@AllUNeedIsLoew
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Our group characterises membrane proteins, using our expertise in cryoEM, crystallography, sybodies, in silico analysis, and liposome assays @EMBLHamburg @EMBL
Joined October 2021
Our work on the thiamine transporter SLC19A3 is online now. Check this out: Cryo-EM structures of SLC19A3 in different conformations, bound to thiamine and various drug molecules. Kudos to @flosangabriel and everybody involved (@EMBLHamburg, @CssbHamburg).
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Finally, out! .MFSD1 functions as a general dipeptide uniporter in lysosomes!.This was a real team effort. Many thanks to @Kathaschnatta, @DammeMarkus, @OceaneGuelle and Bruno Gasnier, @AhmadRezaMehdi1, @abu_remaileh, and everyone else involved!. See:
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New preprint from the lab!.In our work, we show that MFSD1 functions as a novel lysosomal dipeptide uniporter. Big thanks to @DammeMarkus, @OceaneGuelle and Bruno Gasnier, @AhmadRezaMehdi1, @abu_remaileh, and everyone else involved in this work!.
www.biorxiv.org
Lysosomal degradation of macromolecules in lysosomes produces diverse small metabolites exported by specific transporters for reuse in biosynthetic pathways. Here, we deorphanized the Major Facilit...
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RT @janstrauss1: Read our latest #research on how plastid-localized #rhodopsin increases #diatom biomass and ecosystem productivity in iron….
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Out now! .Cryo-EM structure of the lysosomal Peptide/ Histidine Transporter 1 (PHT1/SLC15A4) and a model for its function as TASL receptor. Special thanks to everybody involved (@TniaCustdio2 @EMBLHamburg @CssbHamburg @Boehringer). https: //doi.org/10.1038/s41467-023-41420-5
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RT @EMBLHamburg: Meet Florian Gabriel 🇩🇪, Predoctoral Fellow at EMBL Hamburg. He studies proteins that transport vitamins in our body, and….
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Congratulations to our CSSB housemates on this great achievement! . and also well done on the visuals :).
So excited to finally share these results of my 7 years effort. Thanks the whole @MarlovitsLab team for great support and esp. @DirkFahrenkamp, @nikigoessi! This was a wild ride. starting with a simple question. How does the complex move the DNA - lever is the answer. SOUND ON!
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Only one week left to apply!. Don't miss out on this great opportunity to learn from experts in the field of membrane proteins.
Add your name! Registration is now open until 15 June and abstract submission until 15 August for EMBO Practical Course on Membrane Protein Expression, Purification and Characterization (mPEPC2), 5 – 12 September 2022 in Hamburg, Germany #EMBOmpepc2.
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We thank @EMBLBarcelona and @_JamesSharpe for hosting us on our group retreat to Barcelona. (We slightly envy the view onto the ocean and access to the beach.)
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Here we present our latest EM structure from the lab!. Take a look on biorxiv 😊. Cryo-EM structure of an atypical proton-coupled peptide transporter: Di- and tripeptide permease C
www.biorxiv.org
Proton-coupled Oligopeptide Transporters (POTs) of the Major Facilitator Superfamily (MFS) mediate the uptake of short di- and tripeptides in all phyla of life. POTs are thought to constitute the...
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Fluffy (and tasty) surprise for the lab!. Thanks to the Kotov bakery for these cute muffins. #SweetenTheScience
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RT @EMBOevents: Add your name! Registration is now open until 15 June and abstract submission until 15 August for EMBO Practical Course on….
meetings.embo.org
Integral membrane proteins (IMPs) are encoded by 20-30 % of all open reading frames and provide key functions in the cell. Due to their hydrophobic nature, they are more difficult to study and struct…
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Only ten days left to apply!.
Job opening for a PostDoc!. Our lab has a 2-year position open for structural biologists interested in studying membrane protein complexes in the malaria parasite Plasmodium falciparum. Application is open until 16th Jan 2022. More details in link below:.
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We wish you all a merry Christmas and thank our lab members for their hard work and dedication throughout another year of this pandemic.
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Job opening for a PostDoc!. Our lab has a 2-year position open for structural biologists interested in studying membrane protein complexes in the malaria parasite Plasmodium falciparum. Application is open until 16th Jan 2022. More details in link below:.
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For some of our colleagues, the Nisse game sends them on a quest. Here, Tania (@TniaCustdio2) and Katharina (@Katharina_Ju) had to earn their presents.
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Next up in the Nisse game @CssbHamburg & @EMBLHamburg is Maxime (@BenKlr). He apparently left his lab bench unattended for too long. One has to admire the intricate design of the spider made of pipette tips and a 1.5 ml tube.
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