QT with a photo of you that somebody else has taken. Selfies are not allowed. It can be old or new but ideally one that really captures you.

So honored (!) and excited to see everyone in Albuquerque next week 🥹 🧠 🧬 #OSSD2025

It's clear that many do not understand what @NIH-funded research does to improve health. It's time to revive a study published 10 years ago that provides incredible information about this. link in the comment Every single new drug approved by the FDA from 2010–2016 was built on

We’re growing & still hiring! ✨ DM me if the following combo sounds like your jam: • honing your bioinformatics skills 💻 • focusing on neurogenetics 🧠 🧬 • dissecting disease mechanisms 🔍 • combating discrimination 🌈✌🏼

Beyond happy to see this work published! We show that developmental timing of social brain areas correlates with social and behavioral milestones in marmosets and, as in humans, extends into adulthood. https://t.co/FzX6Ovi0nr

Baby bro has his PhD!!! 🥹💜🥂

Double dose of Dr. DeCasiens comin’ right up!!! 🤓 ⚓️ 📚

I’m thrilled & honored to be starting a new lab @ the NIA!! 🤩🥹 The Computational & Evolutionary Neurogenomics Unit focuses on: • neurodegenerative diseases 🧓🏽 • sex-biased 🧠 aging • comparative neurobio 🐒🐁 We’re looking for postdocs! 👀 Pls RT! DM me for more info ☺️

(1/11🧵) Echoes of fetal development etched into the adult brain 🧠 - Excited to share our new preprint! “A bipolar taxonomy of adult human brain sulcal morphology related to timing of fetal sulcation and trans-sulcal gene expression gradients” https://t.co/TOo9ArvBgU

Sorry for the typo! You can find my amazing PI over here 👉🏽 @bogglerapture ✨

Many thanks to our co-authors & to you for reading!! (11/11)

Limits/gaps include: 1) bulk gene expression data (missing cell type specific and protein-level info) 🫠 2) evolutionary mechanisms driving X vs Y diffs (positive vs relaxed selection) 🐒🦧🦍 3) environmental/social factors that lead to sex/gender diffs 👩🏼‍🦰👨🏽👱🏽👩🏾‍🦱👵🏼🧔🏻🧔🏽‍♀️ (10/11)

#6: Finally, we find that subclasses of ASD risk genes show diff patterns of co-exp. to X vs Y gametologs (bottom panel): regulation-related ASD genes 🟰 X-biased synapse-related ASD genes 🟰 Y-biased ➡️maybe these co-exp. patterns contribute to sex-biased ASD risk? 👀 (9/11)

#5: We predicted (& confirmed ✅) that genes with stronger co-exp. to X (vs Y) gametolog genes ➡️ higher exp. & co-exp. in XX👤 (vs XY👤) (top panel of fig) a.k.a. genes co-regulated with X (vs Y) gametologs tend to be more highly exp. and co-exp. in XX👤 (vs XY👤)❕ (8/11)

We then reasoned that: ⏺️ if diff. X vs Y co-exp. 🟰 each gene’s co-regulation with &/or regulation by X vs Y gametolog genes… ➡️ sex diffs in exp. & co-exp. may be partly organized by gametologs 👀 (in addition to other factors e.g., hormones) 🧩 (7/11)

#4: We also ranked all autosomal genes by their differential co-exp. w/ the X vs Y member of each pair in each tissue (in XY👤) ◼️◾️▪️ ➡️patterns differ across pairs > tissues ➡️groups of genes with similar functions (e.g., synaptic) have similar diff. co-exp. patterns (6/11)

#3: The X vs Y members of some pairs look more diff than others 🤔 One contributor ➡️ X vs Y diffs are greater in gene pairs that are evolutionarily older 👵🏼 ⏰ (i.e., have been separated longer) & have more divergent regulatory (promoter) and protein sequences ▫️◽️◻️ (5/11)

Major findings: #1: Gametolog CFs look different in XX👤 vs XY👤 when we combine across sex chromosomes🧬 So 🟡+🟡 ❌🟰 🟡+🟠 #2: This is driven by divergence between the X vs Y copies in XY👤 (!) since pairs with ⬆️X vs Y diffs also have ⬆️XX vs XY diffs So 🟡❌🟰🟠 (4/11)

Many have answered this Q for specific gene pairs 🧬 & functional readouts (w/ e.g., single molecule techniques🔬) We used X vs Y co-expression fingerprints (CFs) 📈 to measure functional divergence in 40 human tissues ➡️ CFs are applicable to all gene pairs & tissues! (3/11)

Our main Q: Are the Y copies functionally 🟰 to the X copies? This Q may be relevant for sex-biased disease because… XX👤 express 2 X copies 🟡🟡 XY👤 express 1 X & 1 Y copy 🟡🟠 So if X & Y copies function similarly [🟡🟰🟠] Then 🟡🟡🟰🟡🟠 But what if 🟡❌🟰🟠⁉️ (2/11)

New preprint alert!🚨 Do you often find yourself thinking “what’s up with those genes that have (non-recombining) copies on the X & Y chromosomes?!”🧬👀 Probably not…but @bogglecapture & I think about these “gametolog” gene pairs quite a bit!🤔 (1/11) https://t.co/4Fkn2AEIQB